Publication: Effect of linopirdine on forced swimming test in rats
dc.contributor.author | Uzunok, Barış | |
dc.contributor.author | Kahveci, Nevzat | |
dc.contributor.author | Suyen, Güldal Güleç | |
dc.contributor.author | Büyükuysal, M. Çağatay | |
dc.contributor.buuauthor | KAHVECİ, NEVZAT | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı | |
dc.contributor.orcid | 0000-0003-0841-8201 | |
dc.contributor.researcherid | AAG-7070-2021 | |
dc.date.accessioned | 2024-10-14T11:11:59Z | |
dc.date.available | 2024-10-14T11:11:59Z | |
dc.date.issued | 2019-01-01 | |
dc.description.abstract | Objective: In this study, we aimed to investigate the effect of Kv7 type voltage-gated potassium channel blocker linopirdin in Forced Swimming Test (FST) in rats.Material and Method: For this purpose, on the second day of the swimming test, rats received %0.9 NaCl (4 mu l) or a Kv7 type voltage-gated potassium channel blocker linopirdine (0.1, 1, 10 mu g/4 mu l) intracerebroventricularly (i.c.v.), 15 min before the test.Results: Linopirdine at a dose of 0.1 mu g/4 mu l significantly decreased immobilisation (p=0.003) and significantly increased swimming (p<0.01) with respect to the control grup. Linopirdine at the doses of 1 mu g/4 mu l and 10 mu g/4 mu l; i.c.v., significantly decreased immobilisation (p values<0.001) and significantly increased swimming (p=0.003 and p=0.021, respectively), and climbing (p=0.009 and p=0.006, respectively) with respect to the control grup.Conclusion: The results we obtained shows that linopirdine applied through i.c.v way produces similar effects as the anti-depressant drugs in the FST model. Therefore, we believe that drugs that block Kv7 type voltage-gated potassium channels can be considered as antidepressant drug targets. | |
dc.identifier.endpage | 46 | |
dc.identifier.issn | 1305-2381 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 41 | |
dc.identifier.uri | https://hdl.handle.net/11452/46363 | |
dc.identifier.volume | 15 | |
dc.identifier.wos | 000467534400006 | |
dc.indexed.wos | WOS.ESCI | |
dc.language.iso | en | |
dc.publisher | Nobel İlaç | |
dc.relation.journal | Nobel Medicus | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Potassium channel blockers | |
dc.subject | K+ channels | |
dc.subject | Dup 996 | |
dc.subject | Depression | |
dc.subject | Release | |
dc.subject | Model | |
dc.subject | 4-aminopyridine | |
dc.subject | Blockade | |
dc.subject | Increase | |
dc.subject | Basal | |
dc.subject | Linopirdine | |
dc.subject | Depression | |
dc.subject | Potassium channels | |
dc.subject | Forced-swim test | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Medicine, general & internal | |
dc.subject | General & internal medicine | |
dc.title | Effect of linopirdine on forced swimming test in rats | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | d70d0afb-7b5f-4839-a534-4ff5bced5b5a | |
relation.isAuthorOfPublication.latestForDiscovery | d70d0afb-7b5f-4839-a534-4ff5bced5b5a |