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Could mesangial c3 deposition be an independent prognostic marker in immunoglobulin a nephropathy?

dc.contributor.authorÇetinkaya, Hakkı
dc.contributor.authorGürsu, Meltem
dc.contributor.authorYazıcı, Halil
dc.contributor.authorCebeci, Egemen
dc.contributor.authorEren, Necmi
dc.contributor.authorAltıparmak, Mehmet Riza
dc.contributor.authorAkcay, Ömer Faruk
dc.contributor.authorŞahin, Gülizar
dc.contributor.authorDheir, Hamad
dc.contributor.authorBastürk, Taner
dc.contributor.authorAtılgan, Kadir Gökhan
dc.contributor.authorAydemir, Nihal
dc.contributor.authorTurgutalp, Kenan
dc.contributor.authorYılmaz, Murvet
dc.contributor.authorSırali, Semahat Karahisar
dc.contributor.authorTatar, Erhan
dc.contributor.authorMirioğlu, Şafak
dc.contributor.authorKazan, Sinan
dc.contributor.authorAydın, Emre
dc.contributor.authorAydın, Zeki
dc.contributor.authorTürkmen, Kültiğin
dc.contributor.authorKutlay, Sim
dc.contributor.authorKaragöz, Ferdi
dc.contributor.authorÖğütmen, Melike Betül
dc.contributor.authorÖztürk, Savaş
dc.contributor.authorÖzkan, Oktay
dc.contributor.authorYıldız, Nuriye
dc.contributor.authorDincer, Tamer
dc.contributor.authorYaşar, Emre
dc.contributor.authorGök, Mahmut
dc.contributor.authorTürkmen, Aydın
dc.contributor.authorDede, Fatih
dc.contributor.authorDerici, Ülver
dc.contributor.buuauthorBoz, Elif Güllülü
dc.contributor.buuauthorGÜLLÜLÜ BOZ, SAİDE ELİF
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentNefroloji Ana Bilim Dalı
dc.contributor.researcheridCHO-7088-2022
dc.date.accessioned2024-12-04T11:08:01Z
dc.date.available2024-12-04T11:08:01Z
dc.date.issued2023-11-10
dc.description.abstractBackground: Immunoglobulin A nephropathy (IgAN) is a common primary glomerulonephropathy. There is evidence that mesangial C3 deposition plays a role in the development of the disease. The aim of this study was to examine the effect of C3 deposition on the prognosis of IgAN patients.Method: The study included 1135 patients with biopsy-confirmed IgAN from the database of the Turkish Nephrology Association Glomerular Diseases Working Group (TSN-GOLD). Patients were excluded from the study if they were aged < 18 or > 75 years or if C3 staining had not been performed in the immunofluorescent analysis. C3 deposition was defined as an immunofluorescence intensity of C3 >= 2 + within the mesangium. The primary endpoints were the development of end-stage renal disease, a 30% decrease in glomerular filtration rate compared to the basal value or an elevation in proteinuria to a nephrotic level (3.5 gr/day).Results: Mesangial C3 deposition was observed in 603 (53.1%) patients. No statistically significant difference was found at baseline between the groups with and without mesangial C3 deposition, as for age, sex, BMI, proteinuria level, or the presence of hypertension. In the follow-up period with a mean duration of 78 months, no significant difference was found between the two groups regarding the primary endpoints (p = 0.43). A significant correlation between C3 deposition and segmental glomerulosclerosis (S1) according to the Oxford MEST-C classification was found (p = 0.001).Conclusion: Although a correlation was observed between mesangial C3 deposition and the S1 MEST-C classification, mesangial C3 deposition was not a prognostic factor in IgAN.
dc.description.sponsorshipWe would like to express our endless thanks to the Turkish Society of Nephrology, who organized the background of the study, and to the pathologists in each centre for their contributions to patient care and their help in providing these data.
dc.identifier.doi10.1007/s40620-023-01770-1
dc.identifier.endpage932
dc.identifier.issn1121-8428
dc.identifier.issue4
dc.identifier.startpage923
dc.identifier.urihttps://doi.org/10.1007/s40620-023-01770-1
dc.identifier.urihttps://hdl.handle.net/11452/48876
dc.identifier.volume37
dc.identifier.wos001106687900001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.journalJournal Of Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIga nephropathy
dc.subjectOxford classification
dc.subjectValidation
dc.subjectIga nephropathy
dc.subjectComplement
dc.subjectC3 deposition
dc.subjectOxford classification
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectUrology & nephrology
dc.titleCould mesangial c3 deposition be an independent prognostic marker in immunoglobulin a nephropathy?
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Nefroloji Ana Bilim Dalı
relation.isAuthorOfPublication63440f8c-694e-4dff-b787-86d3c7cc2bc6
relation.isAuthorOfPublication.latestForDiscovery63440f8c-694e-4dff-b787-86d3c7cc2bc6

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