Publication:
Short term effect of laparoscopic sleeve gastrectomy on clinical, renal parameters and urinary ngal levels in diabetic and non diabetic obesity

dc.contributor.authorElbasan, Onur
dc.contributor.authorŞişman, P.
dc.contributor.authorPeynirci, Hande
dc.contributor.authorYabacı, Ayşegül
dc.contributor.buuauthorDirican, Melehat
dc.contributor.buuauthorDİRİCAN, MELEHAT
dc.contributor.buuauthorGül, Özen Öz
dc.contributor.buuauthorÖZ GÜL, ÖZEN
dc.contributor.buuauthorCander, Soner
dc.contributor.buuauthorCANDER, SONER
dc.contributor.buuauthorErsoy, Canan
dc.contributor.buuauthorERSOY, CANAN
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.orcid0000-0001-8580-9471
dc.contributor.researcheridAAH-8861-2021
dc.contributor.researcheridAAG-6985-2021
dc.contributor.researcheridAAI-1005-2021
dc.date.accessioned2024-07-10T08:03:18Z
dc.date.available2024-07-10T08:03:18Z
dc.date.issued2019-07-01
dc.description.abstractBackground. Although diseases such as diabetes, hypertension, obstructive sleep apnea and hyperlipidemia are clearly documented as obesity associated diseases, it is not well-known whether obesity causes renal pathologies. The aim of the present study was to evaluate the effect of weight loss following laparoscopic sleeve gastrectomy on clinical, renal parameters and urinary Neutrophil gelatinase-associated lipocalin (NGAL) levels in diabetic and non-diabetic obese patients.Methods. Nineteen morbidly obese patients (10 diabetic and 9 non diabetic) who underwent laparoscopic sleeve gastrectomy were evaluated clinically (anthropometric measurements) and biochemically before surgery and at 6 months from surgery.Results. Significant decreases in weight, BMI, FPG, PPG and HbA1c levels were observed in the diabetic group when the baseline and 6th month parameters of the patients were compared. There was also a significant decrease in SBP and DBP. At 6th month following laparoscopic sleeve gastrectomy, renal parameters such as creatinine, mAlb/creatinine, NGAL/creatinine did not differ in the diabetic group. In the nondiabetic group, serum creatinine levels were significantly decreased, but other renal parameters such as mAlb/creatinine and NGAL/creatinine were not significantly different.Conclusions. Our findings revealed significant decreases in weight, body mass index and glycemic parameters after sleeve gastrectomy in diabetic and non-diabetic patients, while no significant alteration was noted in renal functions, urinary NGAL and microalbumin levels.
dc.identifier.doi10.4183/aeb.2019.349
dc.identifier.endpage354
dc.identifier.issn1841-0987
dc.identifier.issue3
dc.identifier.startpage349
dc.identifier.urihttps://doi.org/10.4183/aeb.2019.349
dc.identifier.urihttps://hdl.handle.net/11452/43120
dc.identifier.volume15
dc.identifier.wos000516880800011
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherEditura Acad Romane
dc.relation.journalActa Endocrinologica-bucharest
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGelatinase-associated lipocalin
dc.subjectAlbumin excretion
dc.subjectBiomarker
dc.subjectInjury
dc.subjectSleeve gastrectomy
dc.subjectObesity
dc.subjectUrinary ngal
dc.subjectKidney
dc.subjectWeight loss
dc.subjectT2dm
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectEndocrinology & metabolism
dc.titleShort term effect of laparoscopic sleeve gastrectomy on clinical, renal parameters and urinary ngal levels in diabetic and non diabetic obesity
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
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relation.isAuthorOfPublication4ebb27f5-06de-45b8-8773-ea3452507df3
relation.isAuthorOfPublication7e655938-5300-4433-810e-24945b8c2774
relation.isAuthorOfPublication1a528bc6-7850-41a4-a7cc-1b7f1aded115
relation.isAuthorOfPublication.latestForDiscovery7eff7706-7a1e-4261-b2f4-81c9c846a21f

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