Publication:
Inherited and acquired immunodeficiencies underlying tuberculosis in childhood

dc.contributor.authorBoisson-Dupuis, Stephanie
dc.contributor.authorBustamante, Jacinta
dc.contributor.authorEl-Baghdadi, Jamila
dc.contributor.authorCamcioglu, Yildiz
dc.contributor.authorParvaneh, Nima
dc.contributor.authorEl Azbaoui, Safaa
dc.contributor.authorAgader, Aomar
dc.contributor.authorHassani, Amal
dc.contributor.authorEl Hafidi, Naima
dc.contributor.authorMrani, Nidal Alaoui
dc.contributor.authorJouhadi, Zineb
dc.contributor.authorAilal, Fatima
dc.contributor.authorNajib, Jilali
dc.contributor.authorReisli, İsmail
dc.contributor.authorZamani, Adil
dc.contributor.authorYosunkaya, Sebnem
dc.contributor.authorGülle-Girit, Saniye
dc.contributor.authorYıldıran, Alişan
dc.contributor.authorCipe, Funda Erol
dc.contributor.authorTorun, Selda Hançerli
dc.contributor.authorMetin, Ayşe
dc.contributor.authorAtıkan, Başak Yıldız
dc.contributor.authorHatipoğlu, Nevin
dc.contributor.authorAydoğmuş, Çiğdem
dc.contributor.authorKılıç, Sara Şebnem
dc.contributor.authorDoğu, Figen
dc.contributor.authorKaraca, Neslihan
dc.contributor.authorAksu, Güzide
dc.contributor.authorKütükcüler, Necil
dc.contributor.authorKeser-Emiroğlu, Melike
dc.contributor.authorSomer, Ayper
dc.contributor.authorTanır, Gönül
dc.contributor.authorAytekin, Caner
dc.contributor.authorAdimi, Parisa
dc.contributor.authorMahdaviani, Seyed Alireza
dc.contributor.authorMamishi, Setareh
dc.contributor.authorBousfiha, Aziz
dc.contributor.authorSanal, Ozden
dc.contributor.authorMansouri, Davood
dc.contributor.authorCasanova, Jean-Laurent
dc.contributor.authorAbel, Laurent
dc.contributor.buuauthorKILIÇ GÜLTEKİN, SARA ŞEBNEM
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik İmmünoloji Anabilim Dalı.
dc.contributor.orcid0000-0001-8571-2581
dc.contributor.researcheridAAH-1658-2021
dc.date.accessioned2024-07-29T13:35:13Z
dc.date.available2024-07-29T13:35:13Z
dc.date.issued2015-03-01
dc.description.abstractTuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb) and a few related mycobacteria, is a devastating disease, killing more than a million individuals per year worldwide. However, its pathogenesis remains largely elusive, as only a small proportion of infected individuals develop clinical disease either during primary infection or during reactivation from latency or secondary infection. Subacute, hematogenous, and extrapulmonary disease tends to be more frequent in infants, children, and teenagers than in adults. Life-threatening primary TB of childhood can result from known acquired or inherited immunodeficiencies, although the vast majority of cases remain unexplained. We review here the conditions conferring a predisposition to childhood clinical diseases caused by mycobacteria, including not only M.tb but also weakly virulent mycobacteria, such as BCG vaccines and environmental mycobacteria. Infections with weakly virulent mycobacteria are much rarer than TB, but the inherited and acquired immunodeficiencies underlying these infections are much better known. Their study has also provided genetic and immunological insights into childhood TB, as illustrated by the discovery of single-gene inborn errors of IFN- immunity underlying severe cases of TB. Novel findings are expected from ongoing and future human genetic studies of childhood TB in countries that combine a high proportion of consanguineous marriages, a high incidence of TB, and an excellent clinical care, such as Iran, Morocco, and Turkey.
dc.description.sponsorshipEuropean Research Council (ERC)- ERC-2010-AdG-268777
dc.description.sponsorshipAgence Nationale de la Recherche (ANR) Norwegian - Agency for Development Cooperation - NORAD - ANR-10-IAHU-01
dc.description.sponsorshipInstitut National de la Sante et de la Recherche Medicale (Inserm)
dc.description.sponsorshipSt. Giles Foundation
dc.description.sponsorshipRockefeller University from the National Center for Research Resources - 8ULTR000043
dc.description.sponsorshipNational Center for Advancing Sciences (NCATS) of the National Institute of Health
dc.description.sponsorshipRockefeller University
dc.description.sponsorshipUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Allergy & Infectious Diseases (NIAID) - U01AI088685 - R01AI089970 - R37AI095983
dc.identifier.doi10.1111/imr.12272
dc.identifier.endpage120
dc.identifier.issn0105-2896
dc.identifier.issue1, Special Issue SI
dc.identifier.startpage103
dc.identifier.urihttps://doi.org/10.1111/imr.12272
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1111/imr.12272
dc.identifier.urihttps://hdl.handle.net/11452/43512
dc.identifier.volume264
dc.identifier.wos000350167200008
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWiley
dc.relation.journalImmunological Reviews
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDisseminated mycobacterium-avium
dc.subjectBacille calmette-guerin
dc.subjectAnhidrotic ectodermal dysplasia
dc.subjectInterferon-gamma-receptor
dc.subjectHyper-igm syndrome
dc.subjectChronic granulomatous-disease
dc.subjectAdult-onset immunodeficiency
dc.subjectBone-marrow-transplantation
dc.subjectNijmegen breakage syndrome
dc.subjectIfn-gamma
dc.subjectPrimary immunodeficiency
dc.subjectHuman genetics
dc.subjectIfn-
dc.subjectChildren
dc.subjectMendelian susceptibility to mycobacterial diseases (msmd)
dc.subjectImmunology
dc.titleInherited and acquired immunodeficiencies underlying tuberculosis in childhood
dc.typeReview
dspace.entity.typePublication
relation.isAuthorOfPublicationcb4f5525-5861-44f7-8234-fc2b376a934d
relation.isAuthorOfPublication.latestForDiscoverycb4f5525-5861-44f7-8234-fc2b376a934d

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