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Determination of the relationships between serum amyloid A, serum calprotectin and fecal calprotectin in healthy and infectious diarrheic calves and their diagnostic significances as inflammatory markers

dc.contributor.authorKarakuş, Adil Ömer
dc.contributor.authorTemizel, Ethem Mutlu
dc.contributor.authorUdum, Duygu
dc.contributor.buuauthorKarakuş, Adil Ömer
dc.contributor.buuauthorTEMİZEL, ETHEM MUTLU
dc.contributor.buuauthorUDUM, DUYGU
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/Veteriner Biyokimya Anabilim Dalı.
dc.contributor.orcid0000-0001-7052-1694
dc.contributor.researcheridJSG-9381-2023
dc.contributor.researcheridECV-4083-2022
dc.contributor.researcheridAAH-5167-2021
dc.date.accessioned2024-10-01T10:41:25Z
dc.date.available2024-10-01T10:41:25Z
dc.date.issued2023-10-11
dc.description.abstractIn this study, serum amyloid A (SAA), serum calprotectin (SCalp) and fecal calprotectin (FCalp) levels were investigated in neonatal calves with infectious diarrhea. Total of 70 calves were divided into E. coli, C. parvum, C. parvum + viral, viral and control groups. Clinical parameters were recorded on days 0 and 7, post treatment. On these days, blood and stool samples were also taken. SAA, SCalp and FCalp levels were measured with commercial ELISA kits. Mean SAA levels on day 0 were measured as 0.54 (0.16-2.18) ng/ml and 38.40 (8.28-83.96) ng/ml for the diarrhea and healthy group, respectively (P < 0.001). Statistically significant difference was also obtained between the diarrhea [68.02 ng/ml 46.66-101.67] and control [24.05 ng/ml 11.92-56] groups in terms of SCalp levels on day 0 (P < 0.001). Cut-off value of SCalp to distinguish E. coli originated diarrhea from viral diarrhea was found to be 70.969 ng/ml (Sens: 94%). FCalp levels on day 0 were 93.08 (22.17-122.88) ng/ml and 87.01 +/- 3.33 ng/ml in the diarrhea and healthy groups, respectively (P = 0.04). Cut-off concentration of FCalp was found to be 91.804 ng/ml (P = 0.0057). In addition, as a result of the logistic regression analysis, FCalp's ability to identify animals with diarrhea was found to be 6.316 times (P = 0.009) higher. The highest levels of SCalp and FCalp measured on day 0 were found among E. coli group. As a result, the importance of FCalp and SCalp in diagnosing the status of infectious diarrhea in calves for the first time in the veterinary literature is emphasized.
dc.identifier.doi10.1016/j.rvsc.2023.105041
dc.identifier.issn0034-5288
dc.identifier.urihttps://doi.org/10.1016/j.rvsc.2023.105041
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0034528823002928?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11452/45596
dc.identifier.volume164
dc.identifier.wos001102779800001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.bap(V) - 2020/1
dc.relation.journalResearch in Veterinary Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCryptosporidium-parvum
dc.subjectHalofuginone lactate
dc.subjectDisease-activity
dc.subjectYoung-children
dc.subjectCalf diarrhea
dc.subjectGut pathogens
dc.subjectBacterial
dc.subjectGastroenteritis
dc.subjectDecoquinate
dc.subjectCalprotectin
dc.subjectSerum amyloid a
dc.subjectCalf
dc.subjectDiarrhea
dc.subjectVeterinary sciences
dc.titleDetermination of the relationships between serum amyloid A, serum calprotectin and fecal calprotectin in healthy and infectious diarrheic calves and their diagnostic significances as inflammatory markers
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication32cdabad-4bba-40b7-b2b6-b36bb228ea66
relation.isAuthorOfPublication42694183-fbe6-458d-885c-647fe536d12d
relation.isAuthorOfPublication.latestForDiscovery32cdabad-4bba-40b7-b2b6-b36bb228ea66

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