Publication: Determination of the relationships between serum amyloid A, serum calprotectin and fecal calprotectin in healthy and infectious diarrheic calves and their diagnostic significances as inflammatory markers
dc.contributor.author | Karakuş, Adil Ömer | |
dc.contributor.author | Temizel, Ethem Mutlu | |
dc.contributor.author | Udum, Duygu | |
dc.contributor.buuauthor | Karakuş, Adil Ömer | |
dc.contributor.buuauthor | TEMİZEL, ETHEM MUTLU | |
dc.contributor.buuauthor | UDUM, DUYGU | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Veteriner Biyokimya Anabilim Dalı. | |
dc.contributor.orcid | 0000-0001-7052-1694 | |
dc.contributor.researcherid | JSG-9381-2023 | |
dc.contributor.researcherid | ECV-4083-2022 | |
dc.contributor.researcherid | AAH-5167-2021 | |
dc.date.accessioned | 2024-10-01T10:41:25Z | |
dc.date.available | 2024-10-01T10:41:25Z | |
dc.date.issued | 2023-10-11 | |
dc.description.abstract | In this study, serum amyloid A (SAA), serum calprotectin (SCalp) and fecal calprotectin (FCalp) levels were investigated in neonatal calves with infectious diarrhea. Total of 70 calves were divided into E. coli, C. parvum, C. parvum + viral, viral and control groups. Clinical parameters were recorded on days 0 and 7, post treatment. On these days, blood and stool samples were also taken. SAA, SCalp and FCalp levels were measured with commercial ELISA kits. Mean SAA levels on day 0 were measured as 0.54 (0.16-2.18) ng/ml and 38.40 (8.28-83.96) ng/ml for the diarrhea and healthy group, respectively (P < 0.001). Statistically significant difference was also obtained between the diarrhea [68.02 ng/ml 46.66-101.67] and control [24.05 ng/ml 11.92-56] groups in terms of SCalp levels on day 0 (P < 0.001). Cut-off value of SCalp to distinguish E. coli originated diarrhea from viral diarrhea was found to be 70.969 ng/ml (Sens: 94%). FCalp levels on day 0 were 93.08 (22.17-122.88) ng/ml and 87.01 +/- 3.33 ng/ml in the diarrhea and healthy groups, respectively (P = 0.04). Cut-off concentration of FCalp was found to be 91.804 ng/ml (P = 0.0057). In addition, as a result of the logistic regression analysis, FCalp's ability to identify animals with diarrhea was found to be 6.316 times (P = 0.009) higher. The highest levels of SCalp and FCalp measured on day 0 were found among E. coli group. As a result, the importance of FCalp and SCalp in diagnosing the status of infectious diarrhea in calves for the first time in the veterinary literature is emphasized. | |
dc.identifier.doi | 10.1016/j.rvsc.2023.105041 | |
dc.identifier.issn | 0034-5288 | |
dc.identifier.uri | https://doi.org/10.1016/j.rvsc.2023.105041 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0034528823002928?via%3Dihub | |
dc.identifier.uri | https://hdl.handle.net/11452/45596 | |
dc.identifier.volume | 164 | |
dc.identifier.wos | 001102779800001 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Elsevier Sci Ltd | |
dc.relation.bap | (V) - 2020/1 | |
dc.relation.journal | Research in Veterinary Science | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Cryptosporidium-parvum | |
dc.subject | Halofuginone lactate | |
dc.subject | Disease-activity | |
dc.subject | Young-children | |
dc.subject | Calf diarrhea | |
dc.subject | Gut pathogens | |
dc.subject | Bacterial | |
dc.subject | Gastroenteritis | |
dc.subject | Decoquinate | |
dc.subject | Calprotectin | |
dc.subject | Serum amyloid a | |
dc.subject | Calf | |
dc.subject | Diarrhea | |
dc.subject | Veterinary sciences | |
dc.title | Determination of the relationships between serum amyloid A, serum calprotectin and fecal calprotectin in healthy and infectious diarrheic calves and their diagnostic significances as inflammatory markers | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 32cdabad-4bba-40b7-b2b6-b36bb228ea66 | |
relation.isAuthorOfPublication | 42694183-fbe6-458d-885c-647fe536d12d | |
relation.isAuthorOfPublication.latestForDiscovery | 32cdabad-4bba-40b7-b2b6-b36bb228ea66 |