Publication: Conscious sedation for endoscopic retrograde cholangiopancreatography: Dexmedetomidine versus midazolam
dc.contributor.author | Kılıç, Neslihan | |
dc.contributor.author | Şahin, Şükran | |
dc.contributor.author | Aksu, Hale | |
dc.contributor.author | Yavaşcaoğlu, Belgin | |
dc.contributor.author | Gurbet, Alp | |
dc.contributor.author | Türker, Gürkan | |
dc.contributor.author | Kadıoğlu, Aslı Güler | |
dc.contributor.buuauthor | Kılıç, Neslihan | |
dc.contributor.buuauthor | Şahin, Şükran | |
dc.contributor.buuauthor | Aksu, Hale | |
dc.contributor.buuauthor | YAVAŞCAOĞLU, BELGİN | |
dc.contributor.buuauthor | GURBET, ALP | |
dc.contributor.buuauthor | TÜRKER, YUNUS GÜRKAN | |
dc.contributor.buuauthor | Kadıoğlu, Aslı Güler | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı. | |
dc.contributor.orcid | 0000-0002-4887-1337 | |
dc.contributor.orcid | 0000-0003-4820-2288 | |
dc.contributor.orcid | 0000-0002-6503-8232 | |
dc.contributor.orcid | 0000-0002-3019-581X | |
dc.contributor.researcherid | A-7994-2018 | |
dc.contributor.researcherid | AAG-9356-2021 | |
dc.contributor.researcherid | AAI-7914-2021 | |
dc.contributor.researcherid | AAI-6642-2021 | |
dc.contributor.researcherid | FDK-6768-2022 | |
dc.contributor.researcherid | DPH-3881-2022 | |
dc.contributor.researcherid | AAO-7943-2020 | |
dc.contributor.researcherid | ILV-9196-2023 | |
dc.date.accessioned | 2024-09-26T07:02:49Z | |
dc.date.available | 2024-09-26T07:02:49Z | |
dc.date.issued | 2011-04-01 | |
dc.description.abstract | Objective: Midazolam and dexmedetomidine, which are used for sedation during endoscopic retrograde cholangiopancreatography, were compared to evaluate the differences in efficacy, hemodynamics, and side effects.Materials and Methods: Fifty patients aged between 18 and 80 were randomly assigned to two groups according to American Society of Anesthesiologists (ASA) classification: Group M received midazolam with an initial bolus infusion of 0.04 mg/kg intravenously (i.v.), followed by additional doses of 0.5 mg i.v. midazolam, titrated to achieve a Ramsay sedation scale score of 3-4. Group D received dexmedetomidine with an initial bolus infusion of 1 mcg/kg/hr i.v. over 10 minutes, followed by a continuous infusion of 0.2-0.7 mcg/kg/hr, titrated to achieve an RSS of 3-4. A Mini Mental Status Examination (MMSE) was performed prior to sedation and in the recovery room once the Modified Aldrete Score (MAS) reached 9-10. Patient heart rates, arterial pressure and pain were evaluated.Results: Patients in Group D had lower heart rates at 20, 25, 30, 35 and 40 minutes following the initiation of sedation (p<0.05). There was no statistical difference in arterial pressure, RSS, MMSE or respiratory rate between the two groups. Coughing, nausea and vomiting occurred in 3 patients in Group M (12%), whereas no patient in Group D experienced these symptoms. The procedure elicited a gag response in 7 patients in Group M (28%) and in 4 patients in Group D (16%), with no significant difference between groups (p>0.05). When patient and surgeon satisfaction was compared between the two groups, Group D showed higher surgeon satisfaction scores (p<0.05).Conclusion: The use of dexmedetomidine for conscious sedation during short, invasive procedures, such as endoscopic retrograde cholangiopancreatography, could be a superior alternative to the use of midazolam. | |
dc.identifier.doi | 10.5152/eajm.2011.03 | |
dc.identifier.endpage | 17 | |
dc.identifier.issn | 1308-8734 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 13 | |
dc.identifier.uri | https://doi.org/10.5152/eajm.2011.03 | |
dc.identifier.uri | https://www.eajm.org//en/conscious-sedation-for-endoscopic-retrograde-cholangiopancreatography-dexmedetomidine-versus-midazolam-132432 | |
dc.identifier.uri | https://hdl.handle.net/11452/45279 | |
dc.identifier.volume | 43 | |
dc.identifier.wos | 000420425500003 | |
dc.indexed.wos | WOS.ESCI | |
dc.language.iso | en | |
dc.publisher | Aves | |
dc.relation.journal | Eurasian Journal of Medicine | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Conscious sedation | |
dc.subject | Ercp | |
dc.subject | Dexmedetomidine | |
dc.subject | Midazolam | |
dc.subject | General & internal medicine | |
dc.title | Conscious sedation for endoscopic retrograde cholangiopancreatography: Dexmedetomidine versus midazolam | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 22870513-5f1d-4e85-9a57-284c8900e112 | |
relation.isAuthorOfPublication | fc04310c-770b-4b0f-89a3-3ed0ffafbc66 | |
relation.isAuthorOfPublication | 676caee1-1849-4d63-9bd6-55785d734078 | |
relation.isAuthorOfPublication.latestForDiscovery | 22870513-5f1d-4e85-9a57-284c8900e112 |
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