Publication:
Conscious sedation for endoscopic retrograde cholangiopancreatography: Dexmedetomidine versus midazolam

dc.contributor.authorKılıç, Neslihan
dc.contributor.authorŞahin, Şükran
dc.contributor.authorAksu, Hale
dc.contributor.authorYavaşcaoğlu, Belgin
dc.contributor.authorGurbet, Alp
dc.contributor.authorTürker, Gürkan
dc.contributor.authorKadıoğlu, Aslı Güler
dc.contributor.buuauthorKılıç, Neslihan
dc.contributor.buuauthorŞahin, Şükran
dc.contributor.buuauthorAksu, Hale
dc.contributor.buuauthorYAVAŞCAOĞLU, BELGİN
dc.contributor.buuauthorGURBET, ALP
dc.contributor.buuauthorTÜRKER, YUNUS GÜRKAN
dc.contributor.buuauthorKadıoğlu, Aslı Güler
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.
dc.contributor.orcid0000-0002-4887-1337
dc.contributor.orcid0000-0003-4820-2288
dc.contributor.orcid0000-0002-6503-8232
dc.contributor.orcid0000-0002-3019-581X
dc.contributor.researcheridA-7994-2018
dc.contributor.researcheridAAG-9356-2021
dc.contributor.researcheridAAI-7914-2021
dc.contributor.researcheridAAI-6642-2021
dc.contributor.researcheridFDK-6768-2022
dc.contributor.researcheridDPH-3881-2022
dc.contributor.researcheridAAO-7943-2020
dc.contributor.researcheridILV-9196-2023
dc.date.accessioned2024-09-26T07:02:49Z
dc.date.available2024-09-26T07:02:49Z
dc.date.issued2011-04-01
dc.description.abstractObjective: Midazolam and dexmedetomidine, which are used for sedation during endoscopic retrograde cholangiopancreatography, were compared to evaluate the differences in efficacy, hemodynamics, and side effects.Materials and Methods: Fifty patients aged between 18 and 80 were randomly assigned to two groups according to American Society of Anesthesiologists (ASA) classification: Group M received midazolam with an initial bolus infusion of 0.04 mg/kg intravenously (i.v.), followed by additional doses of 0.5 mg i.v. midazolam, titrated to achieve a Ramsay sedation scale score of 3-4. Group D received dexmedetomidine with an initial bolus infusion of 1 mcg/kg/hr i.v. over 10 minutes, followed by a continuous infusion of 0.2-0.7 mcg/kg/hr, titrated to achieve an RSS of 3-4. A Mini Mental Status Examination (MMSE) was performed prior to sedation and in the recovery room once the Modified Aldrete Score (MAS) reached 9-10. Patient heart rates, arterial pressure and pain were evaluated.Results: Patients in Group D had lower heart rates at 20, 25, 30, 35 and 40 minutes following the initiation of sedation (p<0.05). There was no statistical difference in arterial pressure, RSS, MMSE or respiratory rate between the two groups. Coughing, nausea and vomiting occurred in 3 patients in Group M (12%), whereas no patient in Group D experienced these symptoms. The procedure elicited a gag response in 7 patients in Group M (28%) and in 4 patients in Group D (16%), with no significant difference between groups (p>0.05). When patient and surgeon satisfaction was compared between the two groups, Group D showed higher surgeon satisfaction scores (p<0.05).Conclusion: The use of dexmedetomidine for conscious sedation during short, invasive procedures, such as endoscopic retrograde cholangiopancreatography, could be a superior alternative to the use of midazolam.
dc.identifier.doi10.5152/eajm.2011.03
dc.identifier.endpage17
dc.identifier.issn1308-8734
dc.identifier.issue1
dc.identifier.startpage13
dc.identifier.urihttps://doi.org/10.5152/eajm.2011.03
dc.identifier.urihttps://www.eajm.org//en/conscious-sedation-for-endoscopic-retrograde-cholangiopancreatography-dexmedetomidine-versus-midazolam-132432
dc.identifier.urihttps://hdl.handle.net/11452/45279
dc.identifier.volume43
dc.identifier.wos000420425500003
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherAves
dc.relation.journalEurasian Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectConscious sedation
dc.subjectErcp
dc.subjectDexmedetomidine
dc.subjectMidazolam
dc.subjectGeneral & internal medicine
dc.titleConscious sedation for endoscopic retrograde cholangiopancreatography: Dexmedetomidine versus midazolam
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication22870513-5f1d-4e85-9a57-284c8900e112
relation.isAuthorOfPublicationfc04310c-770b-4b0f-89a3-3ed0ffafbc66
relation.isAuthorOfPublication676caee1-1849-4d63-9bd6-55785d734078
relation.isAuthorOfPublication.latestForDiscovery22870513-5f1d-4e85-9a57-284c8900e112

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