Publication:
Effect of prechemotherapy filgrastim on the bone marrow toxicity of topotecan

dc.contributor.buuauthorOzan, Hakan
dc.contributor.buuauthorÖzkalemkaş, Fahir
dc.contributor.buuauthorOzan, Ülkü
dc.contributor.buuauthorÖzerkan, Kemal
dc.contributor.buuauthorBilgin, Tevfik
dc.contributor.buuauthorKüçükyıldız, Faruk
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentKadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.contributor.departmentHemotoloji Ana Bilim Dalı
dc.contributor.researcheridAAG-8495-2021
dc.contributor.researcheridAAH-9791-2021
dc.contributor.scopusid7003908072
dc.contributor.scopusid6601912387
dc.contributor.scopusid6507254632
dc.contributor.scopusid6603345841
dc.contributor.scopusid7004103925
dc.contributor.scopusid6504371550
dc.date.accessioned2022-01-05T06:05:39Z
dc.date.available2022-01-05T06:05:39Z
dc.date.issued2001
dc.description.abstractPurpose: To investigate the efficacy and safety of single-dose filgrastim administered 24 hours prior to chemotherapy in the prevention of topotecan-related myeloid suppression. Methods: No medication was given to 21 rats in group I; 1.5 mg/m(2)/day topotecan was administered intraperitoneally for five days every three weeks to 21 rats in group 11; a single dose of 5 mug/kg filgrastim was injected intraperitoneally 24 hours before the intraperitoneal administration of the same dose of topotecan to 21 rats in group M. After completion of six cycles of chemotherapy, the rats were decapitated and blood samples were immediately collected into citrated tubes for complete blood counts. Results: White blood cell and lymphocyte counts in the control and the filgrastim + topotecan groups were similar (p > 0.05) and significantly higher than the counts in the topotecan group (p < 0.05). There was no difference in means of neutrophil, monocyte, eosinophil, basophil and erythrocyte counts among the groups (p > 0.05). Conclusion: Filgrastim administration prior to chemotherapy seems to be beneficial and further investigations are needed.
dc.identifier.citationOzan, H. vd. (2001). "Effect of prechemotherapy filgrastim on the bone marrow toxicity of topotecan". European Journal of Gynaecological Oncology, 22(6), 463-465.
dc.identifier.endpage465
dc.identifier.issn0392-2936
dc.identifier.issue6
dc.identifier.pubmed11874084
dc.identifier.scopus2-s2.0-0035716333
dc.identifier.startpage463
dc.identifier.urihttp://hdl.handle.net/11452/23852
dc.identifier.volume22
dc.identifier.wos000173802900019
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherIMR Press
dc.relation.collaborationYurtiçi
dc.relation.journalEuropean Journal Of Gynaecological Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFilgrastim
dc.subjectMyelosuppression
dc.subjectPrechemotherapy
dc.subjectTopotecan
dc.subjectColony-stimulating factor
dc.subjectEpithelial ovarian-Cancer
dc.subjectGranulocyte
dc.subjectChemotherapy
dc.subjectCarcinoma
dc.subjectInvitro
dc.subjectInvivo
dc.subjectCells
dc.subjectCsf
dc.subjectOncology
dc.subjectObstetrics & gynecology
dc.subject.emtreeRecombinant granulocyte colony stimulating factor
dc.subject.emtreeAnimal model
dc.subject.emtreeTopotecan
dc.subject.emtreeExperiment
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeBasophil
dc.subject.emtreeBone marrow
dc.subject.emtreeBone marrow suppression
dc.subject.emtreeCancer chemotherapy
dc.subject.emtreeCell protection
dc.subject.emtreeControlled study
dc.subject.emtreeDrug efficacy
dc.subject.emtreeEosinophil
dc.subject.emtreeErythrocyte count
dc.subject.emtreeFemale
dc.subject.emtreeMonocyte
dc.subject.emtreeMouse
dc.subject.emtreeNeutrophil
dc.subject.emtreeNonhuman
dc.subject.meshAnimals
dc.subject.meshAntineoplastic agents
dc.subject.meshBlood cell count
dc.subject.meshBone marrow
dc.subject.meshFemale
dc.subject.meshFilgrastim
dc.subject.meshRats
dc.subject.meshRats, wistar
dc.subject.meshTopotecan
dc.subject.scopusPegfilgrastim; Febrile Neutropenia; Granulocyte Colony-Stimulating Factor
dc.subject.wosObstetrics & gynecology
dc.subject.wosOncology
dc.titleEffect of prechemotherapy filgrastim on the bone marrow toxicity of topotecan
dc.typeArticle
dc.wos.quartileQ4
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Kadın Hastalıkları ve Doğum Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Hemotoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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