Publication: The effect of the time from diagnosis to induction therapy on prognosis in patients with acute leukemia undergoing leukapheresis for symptomatic hyperleukocytosis
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Date
2023-04-11
Authors
Pınar, İbrahim Ethem
Özkocaman, Vildan
Ersal, Tuba
Dağtekin, Mehmet Emin
Yalçın, Cumali
Orhan, Bedrettin
Candar, Ömer
Çubukcu, Sinem
Koca, Tuba Güllü
Gürsoy, Vildan
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley
Abstract
IntroductionOur study investigated leukapheresis's effect on delayed induction therapy outcomes in patients with acute leukemia presenting with symptomatic hyperleukocytosis.MethodsThis retrospective cohort study included 30 adult patients diagnosed with acute leukemia who underwent leukapheresis for leukostasis. The patients were divided into the first 24 h and >24 h groups, according to the time from diagnosis to induction therapy (TDT).ResultsThere was no significant difference between the TDT groups regarding complete remission (CR), 4-week mortality, and overall survival (OS) at a median follow-up of 409 days. Tumor lysis syndrome, disseminated intravascular coagulation, and hemoglobin levels were significant in early mortality. In univariate analysis, age, hemoglobin levels, patients' eligibility for intensive chemotherapy, and achieving CR were critical factors for OS.ConclusionThe study findings suggest that waiting for the clinical and laboratory results may be a safe and reasonable approach before assigning patients the best treatment option with leukapheresis.
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Keywords
Acute myeloid-leukemia, Disseminated intravascular coagulation, Single-center, International society, Scoring system, Leukostasis, Impact, Hemostasis, Management, Thrombosis, Acute leukemia, Hyperleukocytosis, Leukapheresis, Leukostasis, Time from diagnosis to treatment, Hematology, Urology & nephrology