Publication:
The effect of tamoxifen on IGF signaling pathway in the mouse ovary

dc.contributor.authorAsmaz, Ender Deniz
dc.contributor.authorZık, Berrin
dc.contributor.buuauthorAsmaz, Ender Deniz
dc.contributor.buuauthorZIK, BERRİN
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı
dc.contributor.orcid0000-0002-1053-6250.
dc.contributor.orcid0000-0001-6468
dc.contributor.researcheridAAH-9810-2021
dc.contributor.researcheridHPG-0648-2023
dc.contributor.researcheridO-9669-2018
dc.date.accessioned2024-10-07T11:27:31Z
dc.date.available2024-10-07T11:27:31Z
dc.date.issued2019-01-01
dc.description.abstractTamoxifen (TAM) is one of selective estrogen receptor modulators used in breast cancer treatment and prevention. The objective of this study was to determine whether or not insulin-like growth factor-I (IGF-1) and its receptor (IGF-1R), has any role in the effect mechanism of TAM on the ovary. Experimentally, animals were divided into three groups as control group (n=20), low dose TAM treatment group (0.5 mg/mouse/day, n=20) and high dose TAM treatment group (1.5 mg/mouse/day, n=20). TAM was injected 0.5 and 1.5 mg/mouse/day for 5 days. Ovarian sections were used to examine the general structure by trichrome staining method and to determine IGF-1 and IGF-1R expressions by immunohistochemical staining method. After the experiment, the presence of atretic follicles and small cystic structures in the TAM-treated animals was determined. Also, antral follicles and the corpus luteum were much less in the high dose TAM group than in the control. TAM did not change the expression of IGF-1 in granulosa cells, but increased the expression of IGF-1R. In TAM groups, IGF-1 and IGF-1R expression were increased in oocytes of follicles and in interstitial cells depending on TAM doses. However, while IGF-1 expression was unchanged in the corpus luteum, decreased in treatment group. TAM generally stimulated IGF-1 and IGF-1R expression in a dose-dependent manner. The results suggest that IGF-1 signaling pathway is involved in the mechanism of action of TAM on the ovary. We may assert that it may be useful to use IGF-1 signaling pathway regulators to adjust the effects of TAM on the ovary.
dc.identifier.doi10.33988/auvfd.498411
dc.identifier.eissn117O695
dc.identifier.endpage350
dc.identifier.issn1300-0861
dc.identifier.issue4
dc.identifier.startpage343
dc.identifier.urihttps://doi.org/10.33988/auvfd.498411
dc.identifier.urihttp://vetjournal.ankara.edu.tr/en/pub/issue/47708/498411
dc.identifier.urihttps://hdl.handle.net/11452/45982
dc.identifier.volume66
dc.identifier.wos000484847800004
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherAnkara Üniversitesi
dc.relation.journalAnkara Üniversitesi Veteriner Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak117O695
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGrowth-factor-i
dc.subjectFollicle-stimulating-hormone
dc.subjectReceptor gene-expression
dc.subjectGranulosa-cells
dc.subjectFactor system
dc.subjectInsulin
dc.subjectBreast
dc.subjectPremenopausal
dc.subjectCancer
dc.subjectAkt
dc.subjectIgf-1
dc.subjectIgf-1r
dc.subjectMouse
dc.subjectOvary
dc.subjectReproduction
dc.subjectTamoxifen
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectVeterinary sciences
dc.titleThe effect of tamoxifen on IGF signaling pathway in the mouse ovary
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationa30427a9-dc3b-4196-927b-d5b5b4e35e1f
relation.isAuthorOfPublication.latestForDiscoverya30427a9-dc3b-4196-927b-d5b5b4e35e1f

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Asmaz_Zık_2019.pdf
Size:
1.54 MB
Format:
Adobe Portable Document Format

Collections