Publication:
Morning blood pressure surge in early autosomal dominant polycystic kidney disease and its relation with left ventricular hypertrophy

dc.contributor.authorYıldız, Abdülmecit
dc.contributor.authorSağ, Saim
dc.contributor.authorGül, Cuma Bülent
dc.contributor.authorGüllülü, Sümeyye
dc.contributor.authorCan, Fatma Ezgi
dc.contributor.authorBedir, Ömer
dc.contributor.authorAydın, Mehmet Fethullah
dc.contributor.authorOruç, Ayşegül
dc.contributor.authorDemirel, Sadettin
dc.contributor.authorAkgür, Suat
dc.contributor.authorGüllülü, Mustafa
dc.contributor.authorErsoy, Alparslan
dc.contributor.buuauthorYILDIZ, ABDULMECİT
dc.contributor.buuauthorSağ, Saim
dc.contributor.buuauthorGÜL, CUMA BÜLENT
dc.contributor.buuauthorGÜLLÜLÜ, NAZMİYE SÜMEYYE
dc.contributor.buuauthorCan, Fatma Ezgi
dc.contributor.buuauthorBedir, Ömer
dc.contributor.buuauthorAydın, Mehmet Fethullah
dc.contributor.buuauthorORUÇ, AYŞEGÜL
dc.contributor.buuauthorDEMİREL, SADETTİN
dc.contributor.buuauthorAKGÜR, SUAT
dc.contributor.buuauthorGÜLLÜLÜ, MUSTAFA
dc.contributor.buuauthorERSOY, ALPARSLAN
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-5665-7402
dc.contributor.orcid0000-0002-0342-9692
dc.contributor.researcheridHIG-9032-2022
dc.contributor.researcheridAAW-9185-2020
dc.contributor.researcheridJGR-6552-2023
dc.contributor.researcheridJSL-7718-2023
dc.contributor.researcheridIVE-3975-2023
dc.contributor.researcheridAAJ-8220-2020
dc.contributor.researcheridAAH-4002-2021
dc.contributor.researcheridAAH-3460-2021
dc.contributor.researcheridEJA-1761-2022
dc.contributor.researcheridJGS-9425-2023
dc.contributor.researcheridAAH-5054-2021
dc.date.accessioned2024-11-07T12:45:31Z
dc.date.available2024-11-07T12:45:31Z
dc.date.issued2021-01-01
dc.description.abstractIntroduction: The activation of the sympathetic nervous system, which usually leads to a swift surge in blood pressure in the morning hours (MBPS) may be the cause of left ventricular hypertrophy (LVH) and endothelial dysfunction (ED) in early autosomal dominant polycystic kidney disease (ADPKD) patients. We studied the association between MBPS and LVH in ADPKD patients with preserved renal functions.Methods: Patients with ADPKD with preserved renal functions were enrolled. Prewaking MBPS was calculated using ambulatory blood pressure monitoring. The patients were categorized as MBPS (>= median) and non-MBPS (<median). Left ventricular mass index (LVMI), endothelial-dependent dilatation (FMD, %), and carotid intima-media thickness (CIMT) evaluated.Results: Fifty-six patients (30 females and 26 males) were enrolled. Gender distribution was similar-among-the-groups. The mean age was higher in the MBPS group (50.1 +/- 13 vs 37.3 +/- 10.3). Urinary albumin (49.5 vs 16 mg/g creatinine, p < 0.001), hs-CRP (0.59 vs 0.37 mg/dl, p = 0.045) LVMI (124 +/- 27.7 vs 95.2 +/- 19.7 g/m(2), p < 0.001) and mean awake SBP surge was higher (42 vs 20 mmHg, p < 0.001) and FMD (%) was lower (14.4 +/- 6.6 vs 18.9 +/- 5.7, p = 0.009) in MBPS group. In the binary logistic regression analysis, the presence of MBPS in model 1 (OR: 6.625, 95% CI [1.048-41.882] p = 0.044), and age in model 2 (OR: 1.160, 95% CI [1.065-1.263] p = 0.001) were the only independent determinant of LVH.Conclusions: MBPS seems to be an important and independent determinant of LVH in ADPKD patients with preserved renal functions. It may be worth assessing the effect of reduction in MBPS as a new therapeutic target to prevent LVH in-patients-with-ADPKD.
dc.identifier.doi10.1080/0886022X.2020.1864403
dc.identifier.endpage230
dc.identifier.issn0886-022X
dc.identifier.issue1
dc.identifier.startpage223
dc.identifier.urihttps://doi.org/10.1080/0886022X.2020.1864403
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/0886022X.2020.1864403
dc.identifier.urihttps://hdl.handle.net/11452/47585
dc.identifier.volume43
dc.identifier.wos000609546600001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.journalRenal Failure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutosomal dominant polycystic kidney disease
dc.subjectLeft ventricular hypertrophy
dc.subjectEndothelial dysfunction
dc.subjectMorning blood pressure surge
dc.subjectUrology & nephrology
dc.titleMorning blood pressure surge in early autosomal dominant polycystic kidney disease and its relation with left ventricular hypertrophy
dc.typeArticle
dspace.entity.typePublication
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