Semisynthesis and pharmacological activities of tetrac analogs: Angiogenesis modulators
No Thumbnail Available
Date
2009-06-15
Journal Title
Journal ISSN
Volume Title
Publisher
Pergamon-Elsevier Science
Abstract
Novel Tetrac analogs were synthesized and then tested. Anti-angiogenesis efficacy was carried out using the Chick Chorioallantoic Membrane (CAM) model and the mouse matrigel model for angiogenesis. Pharmacological activities showed Tetrac can accommodate numerous modifications and maintain anti-angiogenesis activity.
Description
Keywords
Angiogenesis, Esterification, HPLC, Nanopharmaceutical technology, Silylation, Tetrac, Integrin alpha-v-beta-3, Extracellular segment, Crystal-structure, Triiodothyronine, Thyroxine, Ligand, Acid, Pharmacology & pharmacy, Chemistry
Citation
Bridoux, A. vd. (2009). "Semisynthesis and pharmacological activities of tetrac analogs: Angiogenesis modulators". Bioorganic and Medicinal Chemistry Letters, 19(12), 3259-3263.