Publication:
Effect of the direct renin Inhibitor aliskiren in the prevention of experimental contrast-induced nephropathy in the rat

dc.contributor.authorKedrah, Alla Eldeen
dc.contributor.authorArı, Elif
dc.contributor.authorAlahdab, Yeşim
dc.contributor.authorMacunluoğlu, Beyza
dc.contributor.authorAtakan, Aydın
dc.contributor.authorAşıcıoğlu, Ebru
dc.contributor.authorÇakalağaoğlu, Fulya
dc.contributor.authorKoç, Mehmet
dc.contributor.buuauthorGül, Cuma Bülent
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentNefroloji Ana Bilim Dalı
dc.contributor.orcid0000-0003-2467-9356
dc.contributor.researcheridA-7063-2018
dc.contributor.scopusid23988796000
dc.date.accessioned2022-05-20T05:48:56Z
dc.date.available2022-05-20T05:48:56Z
dc.date.issued2012
dc.description.abstractBackground: Renal vasoconstriction, activated by the reninangiotensin system, plays a pivotal role in the pathogenesis of contrast-induced nephropathy (CIN). The purpose of this study was to evaluate the effect of aliskiren, a direct renin inhibitor, for the prophylaxis of experimental CIN in the rat. Methods: Thirty-two Wistar albino rats were divided into four groups of 8 rats each, namely the control (C), aliskiren (A), contrast media (CM) and aliskiren plus contrast media (ACM) groups. Aliskiren was given orally at a dose of 50 mg/kg/day once daily for 5 consecutive days. CIN was induced by intravenous administration of indomethacin, N-nitro-L-arginine methyl ester and high-osmolar contrast medium meglumine amidotrizoate. Renal function parameters, kidney histology and tubular expression of vascular endothelial growth factor were determined. Results: Mean serum creatinine was significantly lower (p < 0.001) and mean creatinine clearance was higher (p < 0.001) in the ACM group compared with the CM group. However, there were no differences between the ACM and CM groups in terms of tubular necrosis, proteinaceous casts, medullary congestion and vascular endothelial growth factor expression. Conclusion: Our preliminary data seem to suggest a potential role of aliskiren for the prophylaxis of CIN in an experimental rat model.
dc.description.sponsorshipDepartment of Nephrology, Marmara University School of Medicine, Istanbul, Turkey
dc.identifier.citationKedrah, A. E. vd. (2012). "Effect of the direct renin Inhibitor aliskiren in the prevention of experimental contrast-induced nephropathy in the rat". Kidney and Blood Pressure Research, 35(6), 425-430.
dc.identifier.endpage430
dc.identifier.issn1420-4096
dc.identifier.issn1423-0143
dc.identifier.issue6
dc.identifier.pubmed22677784
dc.identifier.scopus2-s2.0-84861808237
dc.identifier.startpage425
dc.identifier.urihttps://doi.org/10.1159/000336104
dc.identifier.urihttps://www.karger.com/Article/FullText/336104
dc.identifier.urihttp://hdl.handle.net/11452/26537
dc.identifier.volume35
dc.identifier.wos000314461100005
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherKarger
dc.relation.collaborationYurt içi
dc.relation.journalKidney and Blood Pressure Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPhysiology
dc.subjectUrology & nephrology
dc.subjectCardiovascular system & cardiology
dc.subjectAliskiren
dc.subjectContrast-induced nephropathy
dc.subjectAcute renal failure
dc.subjectExperimental study
dc.subjectConverting enzyme-inhibitors
dc.subjectBlood-pressure
dc.subjectHypertension
dc.subjectBlockade
dc.subjectMedia
dc.subject.emtreeAliskiren
dc.subject.emtreeArginine methyl ester
dc.subject.emtreeCreatinine
dc.subject.emtreeIndometacin
dc.subject.emtreeMeglumine diatrizoate
dc.subject.emtreeVasculotropin
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeArticle
dc.subject.emtreeContrast induced nephropathy
dc.subject.emtreeControlled study
dc.subject.emtreeCreatinine blood level
dc.subject.emtreeCreatinine clearance
dc.subject.emtreeDrug effect
dc.subject.emtreeIn vivo study
dc.subject.emtreeKdney medulla congestion
dc.subject.emtreeKidney disease
dc.subject.emtreeKidney function
dc.subject.emtreeKidney tubule necrosis
dc.subject.emtreeMale
dc.subject.emtreeNonhuman
dc.subject.emtreePriority journal
dc.subject.emtreeProphylaxis
dc.subject.emtreeProtein expression
dc.subject.emtreeRat
dc.subject.emtreeSodium excretion
dc.subject.emtreeTreatment duration
dc.subject.meshAmides
dc.subject.meshAnimals
dc.subject.meshContrast media
dc.subject.meshFumarates
dc.subject.meshKidney diseases
dc.subject.meshMale
dc.subject.meshRandom allocation
dc.subject.meshRats
dc.subject.meshRats, wistar
dc.subject.meshRenin
dc.subject.meshTreatment outcome
dc.subject.scopusPercutaneous Coronary Intervention; Coronary Angiography; Kidney Diseases
dc.subject.wosPhysiology
dc.subject.wosUrology & nephrology
dc.subject.wosPeripheral vascular disease
dc.titleEffect of the direct renin Inhibitor aliskiren in the prevention of experimental contrast-induced nephropathy in the rat
dc.typeArticle
dc.wos.quartileQ3
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Nefroloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS

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