Publication:
Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea

dc.contributor.buuauthorUrsavaş, Ahmet
dc.contributor.buuauthorKaradağ, Mehmet
dc.contributor.buuauthorOral, Arzu Yılmaztepe
dc.contributor.buuauthorDemirdöǧen, Ezgi Şen
dc.contributor.buuauthorOral, Haluk Barbaros
dc.contributor.buuauthorEge, Ercüment
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentMikrobiyoloji ve Enfeksiyon Hastalıkları Ana Bilim Dalı
dc.contributor.departmentGöğüs Hastalıkları Ana Bilim Dalı
dc.contributor.departmentBiyokimya Ana Bilim Dalı
dc.contributor.orcid0000-0003-0463-6818
dc.contributor.orcid0000-0003-0463-6818
dc.contributor.orcid0000-0002-7400-9089
dc.contributor.orcid0000-0002-7400-9089
dc.contributor.researcheridAAI-3169-2021
dc.contributor.researcheridA-5841-2017
dc.contributor.researcheridAAG-8744-2021
dc.contributor.researcheridAAH-9812-2021
dc.contributor.researcheridK-7285-2012
dc.contributor.scopusid8329319900
dc.contributor.scopusid6601970351
dc.contributor.scopusid23091316500
dc.contributor.scopusid14062849300
dc.contributor.scopusid7004498001
dc.contributor.scopusid6701341320
dc.date.accessioned2022-04-22T09:21:45Z
dc.date.available2022-04-22T09:21:45Z
dc.date.issued2008-08
dc.description.abstractObjective: Obesity and obstructive sleep apnea (OSA) and systemic inflammation may interact through biochemical pathways. Neopterin (NP) is a monocyte/macrophage activation marker produced by macrophages in response to interferon-gamma secreted by activated T lymphocytes. This study examines the association between NP, obesity and OSA. Patients and methods: The study included 22 newly diagnosed OSA (+) patients and 18 OSA patients. Subjects with history of coronary artery disease, transplant patients, history of alcohol and drug abuse, history of HIV and any other significant medical. illnesses such as active infections, autoimmune disease, malignancy, liver disease, pulmonary disease (COPD, asthma, ...), neuromuscular disease, patients on immunomodulating therapy or HMG-CoA reductase inhibitors were excluded. Results: There were no significant differences in age, body mass index (BMI), and smoking habits of the OSA (+) patients and OSA (-) patients. Serum NP levels did not show any significant difference between the OSA (+) patients and OSA (-) patients, however, NP levels were positively correlated with BMI (r = 0.320, p = 0.044). There was no significant correlation between NP and any of the polysomnographic parameters. The result of stepwise regression analyses (r 2 = 0.320, p < 0.001) showed that high serum NP levels (p = 0.004) and apnea-hypopnea index (AHI) were a risk factor for elevated Epworth sleepiness score, independent of BMI. Conclusion: We suggest that serum NP levels correlate with BMI. There was a significant relationship between serum NP levels and excessive daytime sleepiness in OSA patients.
dc.identifier.citationUrsavaş, A. vd. (2008). ''Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea". Respiratory Medicine, 102(8), 1193-1197.
dc.identifier.endpage1197
dc.identifier.issn0954-6111
dc.identifier.issue8
dc.identifier.pubmed18579365
dc.identifier.scopus2-s2.0-47249112913
dc.identifier.startpage1193
dc.identifier.urihttps://doi.org/10.1016/j.rmed.2008.02.019
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0954611108000954
dc.identifier.urihttp://hdl.handle.net/11452/26011
dc.identifier.volume102
dc.identifier.wos000258488900016
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherW B Saunders
dc.relation.journalRespiratory Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCardiovascular system & cardiology
dc.subjectRespiratory system
dc.subjectDaytime sleepiness
dc.subjectNeopterin
dc.subjectObesity
dc.subjectSleep apnea
dc.subjectAcute coronary syndromes
dc.subjectInsulin-resistance
dc.subjectArtery-disease
dc.subjectRisk-factor
dc.subjectKappa-b
dc.subjectThickness
dc.subjectMarker
dc.subjectSystem
dc.subject.emtreeAdult
dc.subject.emtreeArousal
dc.subject.emtreeArticle
dc.subject.emtreeGamma interferon
dc.subject.emtreeNeopterin
dc.subject.emtreeBody mass
dc.subject.emtreeClinical article
dc.subject.emtreeControlled study
dc.subject.emtreeDaytime somnolence
dc.subject.emtreeDaytime somnolence
dc.subject.emtreeDaytime somnolence
dc.subject.emtreeHuman
dc.subject.emtreeObesity
dc.subject.emtreePolysomnography
dc.subject.emtreePriority journal
dc.subject.emtreeProtein blood level
dc.subject.emtreeRisk factor
dc.subject.emtreeSleep apnea syndrome
dc.subject.emtreeSleep time
dc.subject.emtreeSmoking habit
dc.subject.emtreeT lymphocyte
dc.subject.meshAdult
dc.subject.meshBiological markers
dc.subject.meshBody mass index
dc.subject.meshCross-sectional studies
dc.subject.meshDisorders of excessive somnolence
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle aged
dc.subject.meshNeopterin
dc.subject.meshObesity
dc.subject.meshPolysomnography
dc.subject.meshSleep apnea, obstructive
dc.subject.scopusNeopterin; Kynurenine; Pteridine Derivative
dc.subject.wosCardiac & cardiovascular systems
dc.subject.wosRespiratory system
dc.titleAssociation between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea
dc.typeArticle
dc.wos.quartileQ2
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Göğüs Hastalıkları Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Biyokimya Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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