Modulation of nesfatin-1-induced cardiovascular effects by the central cholinergic system
dc.contributor.buuauthor | Aydın, Begüm | |
dc.contributor.buuauthor | Güvenç, Gökçen | |
dc.contributor.buuauthor | Altınbaş, Burçin | |
dc.contributor.buuauthor | Niaz, Nasir | |
dc.contributor.buuauthor | Yalçın, Murat | |
dc.contributor.department | Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı. | tr_TR |
dc.contributor.orcid | 0000-0002-5600-8162 | |
dc.contributor.orcid | 0000-0002-9534-736X | |
dc.contributor.orcid | 0000-0002-1413-3651 | |
dc.contributor.researcherid | AAR-6815-2021 | |
dc.contributor.researcherid | AAC-4975-2022 | |
dc.contributor.researcherid | AAG-6956-2021 | |
dc.contributor.researcherid | HLA-3520-2023 | |
dc.contributor.researcherid | IYS-2646-2023 | |
dc.contributor.scopusid | 57194022849 | tr_TR |
dc.contributor.scopusid | 56529426800 | tr_TR |
dc.contributor.scopusid | 55356919300 | tr_TR |
dc.contributor.scopusid | 57060367600 | tr_TR |
dc.contributor.scopusid | 57192959734 | tr_TR |
dc.date.accessioned | 2024-03-26T08:57:54Z | |
dc.date.available | 2024-03-26T08:57:54Z | |
dc.date.issued | 2018-05-03 | |
dc.description.abstract | Nesfatin-1, a peptide whose receptor is yet to be identified, has been shown to be involved in the modulation of feeding, stress, and metabolic responses. Recently, increasing evidence has supported a modulatory role of nesfatin-1 in cardiovascular activity. We have previously reported that nesfatin-1 causes an increase in blood pressure in normotensive and hypotensive rats by increasing plasma catecholamine, vasopressin, and renin levels. Recent reports suggest that nesfatin-1 may activate the central cholinergic system. However, there is no evidence showing an interaction between central nesfatin-1 and the cholinergic system. Therefore, this study aimed to determine whether the central cholinergic system may have a functional role in the nesfatin-1-induced cardiovascular effect observed in normotensive rats. Intracerebroventricular injection of nesfatin-1 caused short-term increases in mean arterial pressure and heart rate responses including bradycardic/tachycardic phases in normotensive animals. Central injection of nesfatin-1 increased the acetylcholine and choline levels in the posterior hypothalamus, as shown in microdialysis studies. Central pretreatment with the cholinergic muscarinic receptor antagonist atropine and/or nicotinic receptor antagonist mecamylamine blocked nesfatin-1-induced cardiovascular effects. In conclusion, the results show that centrally administered nesfatin-1 produces a pressor effect on blood pressure and heart rate responses including bradycardic/tachycardic phases in normotensive rats. Moreover, according to our findings, the central cholinergic system can modulate nesfatin-1-evoked cardiovascular activity. | en_US |
dc.description.sponsorship | College of Pharmacy and Health Sciences, Lipscomb University (CPHS) | en_US |
dc.identifier.citation | Aydın, B. vd. (2018). ''Modulation of nesfatin-1-induced cardiovascular effects by the central cholinergic system''. Neuropeptides, 70, 9-15. | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.npep.2018.05.001 | |
dc.identifier.eissn | 1532-2785 | |
dc.identifier.endpage | 15 | tr_TR |
dc.identifier.issn | 0143-4179 | |
dc.identifier.pubmed | 29751997 | tr_TR |
dc.identifier.scopus | 2-s2.0-85046634362 | tr_TR |
dc.identifier.startpage | 9 | tr_TR |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0143417918300386 | en_US |
dc.identifier.uri | https://hdl.handle.net/11452/40626 | |
dc.identifier.volume | 70 | tr_TR |
dc.identifier.wos | 000440957400002 | tr_TR |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Churchill Livingstone | en_US |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.journal | Neuropeptides | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.relation.tubitak | 215S872 | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Endocrinology & metabolism | en_US |
dc.subject | Neurosciences & neurology | en_US |
dc.subject | Nesfatin-1 | en_US |
dc.subject | Blood pressure | en_US |
dc.subject | Heart rate | en_US |
dc.subject | Posterior hypothalamic choline/acetylcholine | en_US |
dc.subject | Cholinergic muscarinic and nicotinic receptors | en_US |
dc.subject | Thromboxane A2 analog | en_US |
dc.subject | Injected cdp-choline | en_US |
dc.subject | Blood-pressure | en_US |
dc.subject | Hypotensive rats | en_US |
dc.subject | Conscious rats | en_US |
dc.subject | Solitary tract | en_US |
dc.subject | Neurons | en_US |
dc.subject | Brain | en_US |
dc.subject | Involvement | en_US |
dc.subject | Nucleus | en_US |
dc.subject.emtree | Acetylcholine | en_US |
dc.subject.emtree | Choline | en_US |
dc.subject.emtree | Muscarinic receptor | en_US |
dc.subject.emtree | Nesfatin 1 | en_US |
dc.subject.emtree | Neuropeptide | en_US |
dc.subject.emtree | Nicotinic receptor | en_US |
dc.subject.emtree | Unclassified drug | en_US |
dc.subject.emtree | Acetylcholine | en_US |
dc.subject.emtree | Calcium binding protein | en_US |
dc.subject.emtree | Catecholamine | en_US |
dc.subject.emtree | Cholinergic receptor stimulating agent | en_US |
dc.subject.emtree | DNA binding protein | en_US |
dc.subject.emtree | Mecamylamine | en_US |
dc.subject.emtree | Nerve protein | en_US |
dc.subject.emtree | Nucleobindin | en_US |
dc.subject.emtree | Vasoconstrictor agent | en_US |
dc.subject.emtree | Vasopressin derivative | en_US |
dc.subject.emtree | Adult | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Bradycardia | en_US |
dc.subject.emtree | Cardiovascular effect | en_US |
dc.subject.emtree | Cholinergic system | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Heart rate | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Mean arterial pressure | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Posterior hypothalamus | en_US |
dc.subject.emtree | Priority journal | en_US |
dc.subject.emtree | Rat | en_US |
dc.subject.emtree | Tachycardia | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Blood | en_US |
dc.subject.emtree | Blood pressure | en_US |
dc.subject.emtree | Brain | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Hypotension | en_US |
dc.subject.emtree | Metabolism | en_US |
dc.subject.emtree | Sprague dawley rat | en_US |
dc.subject.mesh | Acetylcholine | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood pressure | en_US |
dc.subject.mesh | Brain | en_US |
dc.subject.mesh | Calcium-binding proteins | en_US |
dc.subject.mesh | Catecholamines | en_US |
dc.subject.mesh | Cholinergic agents | en_US |
dc.subject.mesh | DNA-binding proteins | en_US |
dc.subject.mesh | Heart rate | en_US |
dc.subject.mesh | Hypotension | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mecamylamine | en_US |
dc.subject.mesh | Nerve tissue proteins | en_US |
dc.subject.mesh | Rats, sprague-dawley | en_US |
dc.subject.mesh | Vasoconstrictor agents | en_US |
dc.subject.mesh | Vasopressins | en_US |
dc.subject.scopus | Subfornical Organ; Animals; Hypothalamic Paraventricular Nucleus | en_US |
dc.subject.wos | Endocrinology & metabolism | en_US |
dc.subject.wos | Neurosciences | en_US |
dc.title | Modulation of nesfatin-1-induced cardiovascular effects by the central cholinergic system | en_US |
dc.type | Article | en_US |
dc.wos.quartile | Q3 | en_US |
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