Histological assessment of the effect of alpha-tocopherol on fracture healing in rabbits

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dc.contributor.authorÖzkan, S.
dc.contributor.buuauthorDurak, Kemal
dc.contributor.buuauthorSönmez, Gürsel
dc.contributor.buuauthorSarısözen, Bartu
dc.contributor.buuauthorKaya, Metin
dc.contributor.buuauthorÖztürk, Çaǧatay
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Ortopedi ve Travmatoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0003-3133-206Xtr_TR
dc.contributor.researcheridABI-7283-2020tr_TR
dc.contributor.researcheridAAP-7233-2020tr_TR
dc.contributor.researcheridS-6686-2019tr_TR
dc.contributor.scopusid6602850051tr_TR
dc.contributor.scopusid55167435000tr_TR
dc.contributor.scopusid55890736200tr_TR
dc.contributor.scopusid55417963000tr_TR
dc.contributor.scopusid8230555600tr_TR
dc.date.accessioned2022-03-30T08:22:13Z
dc.date.available2022-03-30T08:22:13Z
dc.date.issued2003-01
dc.description.abstractTo investigate the effect of alpha-tocopherol (vitamin E) on fracture healing in rabbits, two groups of 10 rabbits were either injected with alpha-tocopherol (treated) or untreated (controls). The right femurs of both groups were fractured, and the treated group were injected intramuscularly with 20 mg/kg alpha-tocopherol daily for 5 days starting on the day of fracture. After 21 days, histological sections of the fractured region were examined and scored. Fracture healing had progressed further in the alpha-tocopherol group than in the control group. A statistically significant difference between the histological grading of fracture healing in the two groups was found. This difference may result from an antioxidant (alpha-tocopherol) effect on free oxygen radicals in the fracture area. We conclude that alpha-tocopherol may affect fracture healing favourably and might be useful as a therapeutic agent in clinical fracture management.en_US
dc.identifier.citationDurak, K. vd. (2003). “Histological assessment of the effect of alpha-tocopherol on fracture healing in rabbits”. Journal of International Medical Research, 31(1), 26-30.en_US
dc.identifier.endpage30tr_TR
dc.identifier.issn0300-0605
dc.identifier.issue1tr_TR
dc.identifier.pubmed12635530tr_TR
dc.identifier.scopus2-s2.0-0037226366tr_TR
dc.identifier.startpage26tr_TR
dc.identifier.urihttps://doi.org/10.1177/147323000303100104
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/147323000303100104
dc.identifier.urihttp://hdl.handle.net/11452/25432
dc.identifier.volume31tr_TR
dc.identifier.wos000181291300004
dc.indexed.pubmedPubMeden_US
dc.indexed.scopusScopusen_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherSage Publicationsen_US
dc.relation.collaborationYurt içitr_TR
dc.relation.journalJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectResearch and experimental medicineen_US
dc.subjectPharmacology and pharmacyen_US
dc.subjectAlpha-tocopherolen_US
dc.subjectVitamin Een_US
dc.subjectAntioxidanten_US
dc.subjectFracture healingen_US
dc.subjectRabbiten_US
dc.subjectHistological assessmenten_US
dc.subjectOxygen-free-radicalsen_US
dc.subjectVitamin-Cen_US
dc.subjectTissueen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal modelen_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDose responseen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeDrug useen_US
dc.subject.emtreeFemur fractureen_US
dc.subject.emtreeFracture healingen_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRabbiten_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeStatistical analysisen_US
dc.subject.emtreeTissue sectionen_US
dc.subject.emtreeAlpha tocopherolen_US
dc.subject.emtreeAntioxidanten_US
dc.subject.emtreeFree radicalen_US
dc.subject.emtreeOxygenen_US
dc.subject.scopusFracture Healing; Ovx; Osteoporosisen_US
dc.subject.wosMedicine, research and experimentalen_US
dc.subject.wosPharmacology and pharmacyen_US
dc.titleHistological assessment of the effect of alpha-tocopherol on fracture healing in rabbitsen_US
dc.typeArticle
dc.wos.quartileQ4en_US

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