Histological assessment of the effect of alpha-tocopherol on fracture healing in rabbits
Date
2003-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Sage Publications
Abstract
To investigate the effect of alpha-tocopherol (vitamin E) on fracture healing in rabbits, two groups of 10 rabbits were either injected with alpha-tocopherol (treated) or untreated (controls). The right femurs of both groups were fractured, and the treated group were injected intramuscularly with 20 mg/kg alpha-tocopherol daily for 5 days starting on the day of fracture. After 21 days, histological sections of the fractured region were examined and scored. Fracture healing had progressed further in the alpha-tocopherol group than in the control group. A statistically significant difference between the histological grading of fracture healing in the two groups was found. This difference may result from an antioxidant (alpha-tocopherol) effect on free oxygen radicals in the fracture area. We conclude that alpha-tocopherol may affect fracture healing favourably and might be useful as a therapeutic agent in clinical fracture management.
Description
Keywords
Research and experimental medicine, Pharmacology and pharmacy, Alpha-tocopherol, Vitamin E, Antioxidant, Fracture healing, Rabbit, Histological assessment, Oxygen-free-radicals, Vitamin-C, Tissue
Citation
Durak, K. vd. (2003). “Histological assessment of the effect of alpha-tocopherol on fracture healing in rabbits”. Journal of International Medical Research, 31(1), 26-30.