Publication:
The hypotension evoked by visceral nociception is mediated by delta opioid receptors in the periaqdeductal gray

dc.contributor.authorMillington, William R.
dc.contributor.buuauthorÇavun, Sinan
dc.contributor.buuauthorGöktalay, Gökhan
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentTıbbi Farmakoloji Ana Bilim Dalı
dc.contributor.researcheridAAC-9702-2019
dc.contributor.researcheridAAH-1448-2021
dc.contributor.scopusid6507468595
dc.contributor.scopusid6508023759
dc.date.accessioned2022-03-08T10:34:03Z
dc.date.available2022-03-08T10:34:03Z
dc.date.issued2004-09-03
dc.description.abstractThis study tested the hypothesis that the ventrolateral column of the midbrain periaqueductal gray (vlPAG) region mediates the hypotension and bradycardia evoked by visceral nociception. To test this, the local anesthetic lidocaine (2%; 0.5 mul) was microinjected into the vlPAG of halothane-anesthetized rats bilaterally and visceral nociception was induced 2 min later by injecting 5% acetic acid (0.5 ml) intraperitoneally. Acetic acid injection caused an abrupt fall in arterial pressure (-12.2 +/- 2.1 mm Hg) and heart rate (-37 +/- 93 bpm) lasting approximately 15 min. Lidocaine injection into the vlPAG prevented the fall in arterial pressure and heart rate completely. Cobalt chloride (5 mM; 0.2 or 0.5 mul) injection into the vlPAG also prevented nociceptive hypotension but it did not affect the fall in heart rate significantly. Lidocaine pretreatment also inhibited the depressor response caused by intramuscular formalin (5%; 0.2 ml) administration, a model of deep somatic nociception, although it did not prevent the response completely. To determine if opioid receptors mediate the response, selective mu, delta or kappa opioid receptor antagonists were microinjected into the vlPAG 5 min before intraperitoneal (ip) acetic acid administration. Naltrindole, a delta receptor antagonist, inhibited the response significantly but mu and kappa antagonists were completely ineffective. Lidocaine and naltrindole had no effect when injected into the dorsolateral PAG and did not influence cardiovascular function when injected into the vlPAG of saline treated control animals. These data support the hypothesis that the vlPAG mediates the depressor response evoked by visceral nociception and indicate that delta opioid receptors participate in the response.
dc.identifier.citationÇavun, S. vd. (2004). “The hypotension evoked by visceral nociception is mediated by delta opioid receptors in the periaqdeductal gray”. Brain Research, 1019(1-2), 237-245.
dc.identifier.endpage245
dc.identifier.issn0006-8993
dc.identifier.issue1-2
dc.identifier.pubmed15306258
dc.identifier.scopus2-s2.0-4043174740
dc.identifier.startpage237
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2004.06.003
dc.identifier.urihttp://hdl.handle.net/11452/24907
dc.identifier.volume1019
dc.identifier.wos000223710800027
dc.indexed.scopusScopus
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherElsevier
dc.relation.collaborationYurt dışı
dc.relation.journalBrain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVisceral nociception
dc.subjectPain
dc.subjectCentral cardiovascular regulation
dc.subjectPeriaqueductal gray
dc.subjectOpioid receptor
dc.subjectDelta receptor
dc.subjectVentrolateral periaqueductal gray
dc.subjectFos-like immunoreactivity
dc.subjectColorectal distension
dc.subjectNoxious-stimulation
dc.subjectArterial-pressure
dc.subjectInduced analgesia
dc.subject5-HT1A receptors
dc.subjectEscapable pain
dc.subjectMidbrain
dc.subjectMedulla
dc.subjectNeurosciences and neurology
dc.subject.emtreeAcetic acid
dc.subject.emtreeCobalt chloride
dc.subject.emtreeDelta opiate receptor
dc.subject.emtreeDelta opiate receptor antagonist
dc.subject.emtreeHalothane
dc.subject.emtreeKappa opiate receptor antagonist
dc.subject.emtreeLidocaine
dc.subject.emtreeLocal anesthetic agent
dc.subject.emtreeMu opiate receptor antagonist
dc.subject.emtreeNaltrindole
dc.subject.emtreeSodium chloride
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArterial pressure
dc.subject.emtreeArticle
dc.subject.emtreeCardiovascular function
dc.subject.emtreeControlled study
dc.subject.emtreeDepressor response
dc.subject.emtreeHeart rate
dc.subject.emtreeHypotension
dc.subject.emtreeMale
dc.subject.emtreeNociception
dc.subject.emtreeNonhuman
dc.subject.emtreePeriaqueductal gray matter
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtreeViscera
dc.subject.meshAnimals
dc.subject.meshHeart rate
dc.subject.meshHypotension
dc.subject.meshMale
dc.subject.meshNarcotic antagonists
dc.subject.meshPain measurement
dc.subject.meshPeriaqueductal gray
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshReceptors, opioid, delta
dc.subject.scopusPeriaqueductal Gray; Animals; Escape Reaction
dc.subject.wosNeurosciences
dc.titleThe hypotension evoked by visceral nociception is mediated by delta opioid receptors in the periaqdeductal gray
dc.typeArticle
dc.wos.quartileQ2
dc.wos.quartileQ2
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Tıbbi Farmakoloji Ana Bilim Dalı
local.indexed.atPubMed
local.indexed.atWOS
local.indexed.atScopus

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