Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis

dc.contributor.authorChung, Soon Soup
dc.contributor.buuauthorAltınel, Yüksel
dc.contributor.buuauthorOkay, Güven
dc.contributor.buuauthorUğraş, Nesrin
dc.contributor.buuauthorIşık, Ahmet Fatih
dc.contributor.buuauthorÖztürk, Ersin
dc.contributor.buuauthorÖzgüç, Halil
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Kliniği.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tekstil Mühendisliği Fakültesi/Tekstil Bölümü.tr_TR
dc.contributor.researcheridAAL-9231-2020tr_TR
dc.contributor.researcheridAAH-2716-2021tr_TR
dc.contributor.scopusid26657125600tr_TR
dc.contributor.scopusid57204588493tr_TR
dc.contributor.scopusid55386535600tr_TR
dc.contributor.scopusid56217319800tr_TR
dc.contributor.scopusid35070171400tr_TR
dc.contributor.scopusid6603867989tr_TR
dc.date.accessioned2024-01-15T05:56:56Z
dc.date.available2024-01-15T05:56:56Z
dc.date.issued2018-09
dc.description.abstractBACKGROUND: We evaluated the feasibility of chitosan-coated sutures for intestinal anastomosis strength through wound-healing effect. METHODS: Vicryl and PDS sutures were coated with 2% chitosan. While laparotomy was applied to the first group, chitosan was applied in the peritoneal cavity in the second group. Then the following materials were applied to colon anastomosis, in order: Vicryl, PDS, chitosan-coated Vicryl, and chitosan-coated PDS sutures. On the 7th and 14th days, eight rats from each group were euthanized. RESULTS: The adhesion scores of chitosan and control groups were lower than the suture groups. The vascularization of Vicryl-chitosan was lower than PDS-chitosan on the 14th day (p=0.038). Fibroblast cells and vascularization of anastomosis with chitosan-coated Vicryl were lower than Vicryl and chitosan-coated PDS on the 14th day (p<0.05). The tensile strength of Vicryl-chitosan increased more than Vicryl in vitro (p<0.05) on the 14th and 7th days, but there was no difference in vivo. The tensile strength of PDS-chitosan decreased more than PDS on the 7th day in vivo (p<0.05). CONCLUSION: The chitosan-coating effect on the adhesion and reinforcement of anastomosis in some parts of Vicryl in vitro and PDS in vivo was slightly improved.en_US
dc.identifier.citationAltınel, Y. vd. (2018). ''Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis''. Ulusal Travma ve Acil Cerrahi Dergisi, 24(5), 405-411.en_US
dc.identifier.doihttps://doi.org/10.5505/tjtes.2018.59280en_US
dc.identifier.endpage411tr_TR
dc.identifier.issn1306-696X
dc.identifier.issue5tr_TR
dc.identifier.pubmed30394492tr_TR
dc.identifier.scopus2-s2.0-85056273699tr_TR
dc.identifier.startpage405tr_TR
dc.identifier.urihttps://jag.journalagent.com/travma/pdfs/UTD-59280-RESEARCH_ARTICLE-ALTINEL.pdfen_US
dc.identifier.urihttps://hdl.handle.net/11452/39004
dc.identifier.volume24tr_TR
dc.identifier.wos000446506600005
dc.indexed.pubmedPubMeden_US
dc.indexed.wosSCIEen_US
dc.language.isoenen_US
dc.publisherTürk Travma ve Acil Cerrahi Derneğitr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.relation.journalUlusal Travma ve Acil Cerrahi Dergisitr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEmergency medicineen_US
dc.subjectAnastomosisen_US
dc.subjectChitosanen_US
dc.subjectPDS sutureen_US
dc.subjectTensile strengthen_US
dc.subjectVicryl sutureen_US
dc.subjectWound healingen_US
dc.subjectIn-vitroen_US
dc.subjectPostsurgical adhesionsen_US
dc.subjectPeritoneal adhesionen_US
dc.subjectRepairen_US
dc.subjectReductionen_US
dc.subjectTensileen_US
dc.subject.emtreeChitosanen_US
dc.subject.emtreeCollagenen_US
dc.subject.emtreeBiocompatible coated materialen_US
dc.subject.emtreeAngiogenesisen_US
dc.subject.emtreeAnimal experimenten_US
dc.subject.emtreeAnimal tissueen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCell infiltrationen_US
dc.subject.emtreeColon anastomosisen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDevice safetyen_US
dc.subject.emtreeEvaluation studyen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeFibroblasten_US
dc.subject.emtreeHistopathologyen_US
dc.subject.emtreeInflammatory cellen_US
dc.subject.emtreeIntestine surgeryen_US
dc.subject.emtreeLaparotomyen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreeRaten_US
dc.subject.emtreeRisk assessmenten_US
dc.subject.emtreeScoring systemen_US
dc.subject.emtreeSuture techniqueen_US
dc.subject.emtreeTensile strengthen_US
dc.subject.emtreeTissue adhesionen_US
dc.subject.emtreeWound healingen_US
dc.subject.emtreeAnastomosisen_US
dc.subject.emtreeAnimalen_US
dc.subject.emtreeColonen_US
dc.subject.emtreeDrug effecten_US
dc.subject.emtreeProceduresen_US
dc.subject.emtreeSurgeryen_US
dc.subject.emtreeSutureen_US
dc.subject.emtreeTissue adhesionen_US
dc.subject.emtreeWound healingen_US
dc.subject.meshAnastomosis, surgicalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChitosanen_US
dc.subject.meshCoated materials, biocompatibleen_US
dc.subject.meshColonen_US
dc.subject.meshRatsen_US
dc.subject.meshSuturesen_US
dc.subject.meshTissue adhesionsen_US
dc.subject.meshWound healingen_US
dc.subject.scopusSutures; Triclosan; Surgical Infectionen_US
dc.subject.wosEmergency medicineen_US
dc.titleEffect of chitosan coating on surgical sutures to strengthen the colonic anastomosisen_US
dc.typeArticleen_US
dc.wos.quartileQ4 (Emergency medicine)en_US

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