Browsing by Author "Aydoğan, Kenan"

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A report of 13 cases of merkel cell carcinoma: Single-center experience and review of the literature
(Korean Dermatological Assoc, 2019-06-01) Yazıcı, Serkan; Yazıcı, Elif Irmak; Adım, Şaduman Balaban; Başkan, Emel Bülbül; Aydoğan, Kenan; Sarıcaoğlu, Hayriye; YAZİCİ, SERKAN; Yazıcı, Elif Irmak; BALABAN ADIM, ŞADUMAN; BÜLBÜL BAŞKAN, EMEL; AYDOĞAN, KENAN; SARICAOĞLU, HAYRİYE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji ve Zührevi Hastalıklar Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0001-6407-0962; 0000-0002-0193-1128; AAH-1388-2021; AAH-2459-2021; AAH-6216-2021; IHQ-3086-2023; EMN-0789-2022; DPU-8534-2022
Background: There is limited data knowledge of Merkel cell carcinoma (MCC) in Turkey aside from a few case reports. Objective: The aim of this study was to describe the clinical characteristics, demographic features, therapeutic parameters, and outcome of primary cutaneous MCC cases from Turkey. Methods: Digital medical records of the 13 MCC patients who were followed-up at a tertiary referral center were retrospectively analyzed. Clinic, demographic, tumor characteristics, and survival of the patients were retrieved. Results: Most of our patients were elderly. Female predominance was noticed. The most common primary site of the tumors was the lower extremities. The overall survival was 42 months, 68% at first year, 68% at third years, and 29% at fifth years. Conclusion: This is the first largest report from Turkish population with female predominance, and lower extremity tendency.
Acitretin-induced subungual hemorrhage
(Wiley, 2007-04-30) Aydoğan, Kenan; Karadoğan, Serap Köran; Tunalı, Şükran; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; 0000-0002-0193-1128; 9739755800; 9738885800; 7004191748
A 20-year-old woman with a 2-year history of histologically confirmed palmoplantar keratoderma due to psoriasis, resistant to several topical agents, was admitted to the Department of Dermatology, Uludag University, Bursa, Turkey. Therapy with oral acitretin (0.5mg/kg/day, 35mg/day) was initiated. A month after starting acitretin treatment, she noted slight reddening of the second left fingernail. Clinical examination revealed red-brown discoloration of the second fingernail associated with subungual hemorrhage involving the proximal nail bed (lunula region) (Fig. 1). The nail change was asymptomatic. The patient complained only of discoloration underneath the nail plate. No abnormalities were detected on the skin, mucous membranes, or toenails/ other fingernails. The patient denied exposure to microtrauma or any other drugs. The erythrocyte sedimentation rate, full blood cell count, electrolytes, renal and hepatic tests, and serum lipids were normal. Coagulation tests, including blood clotting time, international normalized ratio, activated partial thromboplastin time, thrombin time, platelet number, and function tests, were within normal levels. Treatment with acitretin was discontinued, and the nail change resolved completely after 3 weeks. A similar episode of subungual hemorrhage recurred, however, within 48 h after re-challenge with a lower dose of acitretin (25 mg/day). The drug was definitively stopped and the eruption faded again within a week. An objective causality assessment suggests that subungual hemorrhage was probably related to acitretin in this patient.
Acrodermatitis dysmetabolica with argininosuccinate lyase deficiency
(Scientific Scholar Llc, 2023-11-01) Öztürk, Ferdi; ÖZTÜRK, FERDİ; SARICAOĞLU, HAYRİYE; Ünlü, Cansu Irmak; ÜNLÜ, CANSU IRMAK; Sarıcaoğlu, Hayriye; Aydoğan, Kenan; AYDOĞAN, KENAN; Erdöl, Şahin; ERDÖL, ŞAHİN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; G-2588-2013
Adult-onset Langerhans cell histiocytosis confined to the skin
(Wiley, 2006) Aydoğan, Kenan; Tunalı, S.; Karadoğan, Koran S.; Adım, Sadiman Balaban; Turan, Hatice Nur; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-0193-1128; AAH-6216-2021; 9739755800; 7004191748; 14047086200; 16835681500
Langerhans cell histiocytosis (LCH) is a clonal, pleo-morphic disease of unknown aetiology, with theaccumulation of local or disseminated atypical histiocyticcells staining positively for S-100 and CD-1a, and causingdamage in the bones, lungs, mucocutaneous structuresand endocrine organs.1 The condition is generally dia-gnosed in infancy and childhood, but onset in adulthoodcan occasionally occur. The eruption is usually diffuse ormanifests as part of a multisystemic disease, and up to 25–50% of patients with LCH will present initially with acutaneous rash.1–5 Cutaneous manifestations are hetero-genous and similar both in children and adults.1,2 LCHconﬁned to the skin is uncommon among reported casesof adults.2–8 We describe a rare case of adult-onset LCHpresenting as cutaneous lesions located symmetrically onthe scalp, groin and inframammarian areas, and review theliterature for previous adult cases of isolated cutaneousLCH.
Anogenital human papillomavirüs (HPV) enfeksiyonlarında sitokin ve mannoz bağlayıcı lektin(MBL) gen polimorfizminin belirlenmesi
(Uludağ Üniversitesi, 2012) Aydoğan, Kenan; Özakın, Cüneyt; Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Tıbbi Mikrobiyoloji Anabilim Dalı.
Human papillomavirüsler (HPV), Papillomavirüsler ailesinden zarfsız, çift sarmallı DNA virüsleridir. 100'den fazla farklı tipte sınıflandırılırlar. Anogenital HPV enfeksiyonları (Kondilomata aküminata; KA) son yıllarda giderek artan bir şekilde önemli infeksiyöz ajanlar olarak tanınmaktadırlar. Kondilomata aküminatalı hastalarda, yardımcı T hücresi 1 (Th1) ve Th2 sitokinleri arasındaki dengenin antiviral immüniteyi düzenlediği düşünülmektedir. Sitokin üretim kapasitesi çeşitli sitokin gen polimorfizmleri ile ilişkili olduğu için sitokinleri kodlayan sitokin genleri konağın HPV enfeksiyonuna yatkınlığında önemli rol oynayabilir. Mannoz bağlayıcı lektin (MBL) fagositozu ve kompleman aktivasyonunu düzenleyen bir serum lektinidir ve doğal immünitenin bir üyesidir. MBL gen polimorfizmleri de MBL üretim miktarı ile ilişkilidir. Mannoz bağlayıcı gen polimorfizmlerinin birçok enfeksiyon hastalığı ile ilişkisi ortaya konmuştur.Bu çalışmada sitokin ve MBL gen polimorfizmi ile anogenital HPV enfeksiyonları arasındaki ilişki incelenmiştir.Bu amaçla çalışmaya KA tanısı almış 40 hasta ve 40 sağlıklı gönüllü alındı. Bu hastaların tamamı en az bir tedaviye (elektrokoterizasyon, kriyoterapi, topikal imikimod, kimyasal ablatif yöntemler vb.) cevap vermeyen ve rekürren lezyonlara sahip olan hastalardı. Sitokin gen polimorfizmleri (Th1 sitokinleri; tümor nekrozis faktör alfa (TNF-?) ve interferon gama (IFN-?), Th2 sitokin; interlökin 6(IL-6), T düzenleyici/baskılayıcı sitokinler IL-10 ve transforming growth factor beta-TGF-ß) sekans spesifik primerler kullanarak Polimeraz Zincir Reaksiyonu- Sekans Spesifik Primer (PCR-SSP) yöntemi ile, MBL gen polimorfizmi ise PCR- Restriction Fragment Lenght Polymorphism (RFLP) yöntemi ile çalışıldı. Aglomeratif hiyerarjik kümeleme analizi yardımıyla olguları iki majör kümeye ayrıldı ve IL-6 ve MBL genotip dağılımlarında anlamlı farklılıklar bulundu. IL-6(-174); G/G görülme oranı hastaların fazla olduğu kümede (küme 1) anlamlı olarak daha fazla iken (p<0.001), G/C görülme oranı sağlıklıların fazla olduğu kümede (küme 2) anlamlı olarak daha fazlaydı (p=0.046). MBL (kodon 54); AA görülme oranı küme 1'de anlamlı olarak daha fazla iken (p<0.001), AB görülme oranı küme 2'de anlamlı olarak daha fazlaydı (p<0.001).Bu çalışmadaki sonuçlar, IL-6 G/G ve MBL AA gen polimorfizmlerinin anogenital HPV enfeksiyonlarının gelişimi ve rekürrensi için bir risk faktörü, IL-6 G/C ve MBL AB polimorfizminin ise koruyucu bir faktör olabileceğini göstermektedir. Türkiye'de anogenital HPV enfeksiyonlarının insidansı gittikçe artmaktadır. Bu nedenle anogenital HPV enfeksiyonlarının patogenezinde gen polimorfizmlerinin rolü için geniş serili çalışmalara ihtiyaç vardır.
Audiological abnormalities in patients with vitiligo
(Wiley, 2006) Aydoğan, Kenan; Turan, O. F.; Onart, Selçuk; Karadoğan, Serap K.; Tunalı, Şükran; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı/Baş Boyun Cerrahisi.; 0000-0002-0193-1128; AAH-6216-2021
Background. Accumulating evidence suggests that vitiligo is a systemic disease affecting the entire pigmentary system. Aim. To investigate the subclinical abnormalities of melanin-containing cellular elements of the auditory system in patients with vitiligo. Methods. We studied the conventional audiometric investigations and brainstem auditory evoked responses (BAERs) of 57 active patients with vitiligo and 50 healthy human subjects. The I, III and V latencies, and I-III, III-V and I-V interpeak latencies (IPL) between the groups were compared. Results. A mild degree of sensorineural hypoacusis was found in eight patients with vitiligo (14%), whereas no controls demonstrated abnormal audiological results (P = 0.006). A statistically significant increase in both ears of the third peak latency (P = 0.02, P = 0.01, respectively) and IPL I-III (P = 0.04, P = 0.008, respectively), and a significant increase of the fifth peak latency in the right ear (P = 0.04) were found, compared with controls, but no differences were found for other latencies and IPLs. Conclusions. Melanin may play a significant role in the establishment and/or maintenance of the structure and function of the auditory system and may modulate the transduction of the auditory stimuli by the inner ear.
Borrelial lymphocytoma cutis successfully treated with intralesional interferon-alpha-2A
(Wiley, 2006-09) Aydoğan, Kenan; Karadoğan, S. Koran; Adım, Şaduman Balaban; Tunalı, S.; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-0193-1128; AAH-6216-2021; 9739755800; 14047086200; 14046617400; 7004191748
Scrofuloderma is increasingly being recognized as themost common form of cutaneous tuberculosis in adults.2,3It results from contiguous involvement of the skinoverlying tuberculosis in a deeper structure, mostcommonly a lymph node, bone, joint or epididymis.2 Bothour patients had cervical glands disease, which is the mostcommon site of involvement in scrofuloderma.4 It haspreviously been suggested that cervical gland involve-ment in tuberculosis may be related to consumption ofunpasteurized milk, leading to infection of the tonsils andsubsequently of the cervical lymph glands by Mycobacte-rium bovis.5 Our patients admitted to boiling milk beforeconsumption.The incidence of systemic tuberculosis in children withcutaneous tuberculosis has been noted to be between21.2%5 and 26%.6 The incidence of systemic involvementin adults with scrofuloderma has been found to be as highas 35%.2 There was no evidence of systemic tuberculosisin our patients. DNA polymerase chain reaction andBACTEC are the ideal techniques for the diagnosis ofcutaneous tubercular infections, but their availability andcosts are major limitations.6 We failed to ﬁnd any reportin literature indicating a particular genetic predispositionto cutaneous tuberculosis. But the occurrence of a speciﬁcform of cutaneous tuberculosis in these siblings mayindicate activity of a common genetically mediatedimmunological pathway.
A case of subcorneal pustular dermatosis treated successfully with a combination of cyclosporin and prednisolone
(Wiley, 2007-04) Karadoǧan, Serap Köran; Aydoğan, Kenan; Bülbül, Emel Başkan; Tunalı, Şükran; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; 0000-0002-0144-3263; AAH-1388-2021; 9738885800; 9739755800; 6602518817; 7004191748
Clinical and demographical characteristics of familial Behcet's disease (southeast Marmara region)
(Karger, 2019-01-01) Kalın, Zübeyde Ceylan; Sarıcaoğlu, Hayriye; Yazıcı, Serkan; Aydoğan, Kenan; Başkan, Emel Bülbül; SARICAOĞLU, HAYRİYE; YAZİCİ, SERKAN; AYDOĞAN, KENAN; BÜLBÜL BAŞKAN, EMEL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji ve Zührevi Hastalıklar Anabilim Dalı.; 0000-0001-6407-0962; 0000-0002-0193-1128; AAH-2459-2021; AAH-6216-2021; AAH-1388-2021; DQE-8993-2022
Background: Familial aggregation in Behcet's disease (BD) has been reported in Turkish and Japanese populations. While the frequency of familial cases has been reported to be 2-5% worldwide, this rate reaches up to 15% in the Middle East. Objective: This study aimed to determine the incidence of familial BD cases followed in the BD polyclinic and to compare their clinical and demographic characteristics to those observed in sporadic cases. Methods: Data related to BD patients who were followed between 1995 and 2014 were collected from computerized archive records and were assessed for detailed family histories. Only first-degree relatives (brother, sister, mother, father, children) were considered to be cases of familial BD. Clinical and demographic features were retrieved. Our BD polyclinic is located in the Southeast Marmara Region in Turkey. Results: BD was detected in 36 first-degree relatives of 33 patients out of 840 patients with BD. A total of 45 patients were diagnosed as familial BD; 23 were female, and 22 were male. In our patients, the incidence of familial BD was determined to be 3.9%. The rates for HLA-B5 positivity, ocular involvement, genital ulcers, and erythema nodosum were determined to be 86.6% (26/30), 26.6%, 82.2%, and 60%, respectively. None of the patients had neurological involvement, but 2 had vascular involvement. Conclusion: This study may contribute to the epidemiological data of BD from Turkey. (C) 2019 S. Karger AG, Basel
Cyclosporine-A for severe childhood atopic dermatitis: Clinical experience on efficacy and safety profile
(TÜBİTAK, 2018-06-23) Sarıcaoğlu, Hayriye; Yazıcı, Serkan; Zorlu, Özge; Bülbül, Başkan Emel; Aydoğan, Kenan; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji ve Zührevi Hastalıklar Anabilim Dalı.; 0000-0001-5555-130X; 0000-0001-6407-0962; JDD-8680-2023; AAH-2459-2021; ABD-1191-2021; 6603722836; 25925620000; 57203899392; 6602518817; 9739755800
Background/aim: Management of atopic dermatitis (AD) in children is still challenging. The aim of this study was to evaluate the efficacy and safety profile of cyclosporine-A (CsA) treatment in children with severe and recalcitrant AD. Materials and methods: Medical records of 43 children followed between January 2010 and December 2015 and treated with systemic CsA were evaluated retrospectively. Treatment efficacy was assessed according to the physician's global assessment (PGA) score. According to the treatment response, patients were grouped as nonresponder, moderate responder, or good responder. Effects of the variables on treatment response were evaluated by analysis of variance (ANOVA). The safety profile of CsA was assessed by clinical and laboratory findings at each visit. Results: The median initial dose of CsA was 3 mg/kg daily, ranging between 2.5 and 5 mg/kg daily. The mean duration of CsA therapy was 4.9 +/- 4.24 months. Seventeen patients (39.5%) achieved good response in a treatment period of 3 to 14 months. After discontinuation of CsA, of the 17 patients, relapse was observed in 4(23.5%). Moderate response was observed in 12(27.9%) patients; however, 14 (32.6) patients did not respond to the treatment. Five patients reported mild side effects. Conclusion: Low-dose CsA seems to be an effective and safe treatment option for severe and recalcitrant AD in children.
Effects of Malassezia yeasts on serum Th1 and Th2 cytokines in patients with guttate psoriasis
(Wiley, 2013-01) Aydoğan, Kenan; Töre, Okan; Akçağlar, Sevim; Oral, Haluk Barbaros; Ener, Beyza; Tunalı, Şükran; Sarıcaoğlu, Hayriye; Uludağ Üniversitesi/Tıp Fakültesi/Dermotoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.; 0000-0002-4803-8206; 0000-0003-0463-6818; 0000-0002-0193-1128; 0000-0002-4759-9634; AAG-8523-2021; AAH-6216-2021; K-7285-2012; 9739755800; 6505909596; 6506194958; 7004498001; 15053025300; 7004191748; 6603722836
Background Systemic and focal infections caused by microorganisms have been known to induce or exacerbate psoriasis. Although the role of yeast species of the genus Malassezia in the pathogenesis of psoriasis is not fully understood, it is thought that these lipophilic yeasts may represent a triggering factor in the exacerbation of psoriatic lesions. Objectives This study investigated the effects of Malassezia yeasts on serum Th1 and Th2 cytokines in patients with guttate psoriasis (GP) in order to define their role in the pathogenesis of psoriasis. Methods Fifty patients with GP and 29 clinically healthy individuals were included in the study. All samples consisted of scales and scrapings taken from the scalps, trunks, and upper limbs of both psoriasis patients and healthy subjects. Psoriasis patients and healthy subjects were grouped according to their positivity or negativity for Malassezia yeasts as ascertained by direct microscopy and/or culture. An enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of Th1 and Th2 cytokines in these groups. Results No significant differences in positivity for Malassezia yeasts were found between psoriatic skin and healthy skin in samples taken from different body sites. Serum interleukin-13 (IL-13) levels were significantly lower in the psoriasis group compared with the control group (P = 0.04). Levels of other cytokines did not differ significantly between the psoriasis and control groups. Mean levels of Th2 cytokines (IL-4, IL-10, IL-13), but not of Th1 cytokines (IL-2 and IFN-?), were significantly lower in psoriasis patients positive for Malassezia yeasts compared with those negative for Malassezia yeasts and control subjects (P = 0.04, P < 0.001 and P = 0.01, respectively). Conclusions The isolation of Malassezia yeasts from GP lesions does not necessarily mean that these species are pathogenic, but their downregulating effects on anti-inflammatory Th2 cytokines may contribute to the occurrence of GP.
Effects of oral isotretinoin therapy on peripheral nerve functions: A preliminary study
(Wiley, 2007-01) Aydoğan, Kenan; Karlı, Nejdet; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabiilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Bölümü.; 0000-0002-0193-1128; AAH-6216-2021; 9739755800; 6506587942
Accumulating evidence over the past decade indicates that synthetic retinoids may be capable of affecting both growth and differentiation of nervous tissue. Our aim was to substantiate possible side-effects of oral isotretinoin therapy on peripheral nerve functions, both neurologically and neurophysiologically. We performed neurological examination and electroneuromyographic studies on 18 patients with various skin diseases before, at the third month, and at the end of isotretinoin treatment. Abnormal neurophysiological findings in this study point towards a typical distal, length-dependent and predominantly sensory polyneuropathy. Clinicians should be aware of possible neurological sensorial symptoms during isotretinoin therapy. In our opinion, electroneuromyographic investigation should be performed on all patients reporting symptoms (e.g. paresthesia, numbness, sensory loss) before and during oral isotretinoin treatment. The precise clinical significance of the isotretinoin-induced neurophysiological alterations reported here remains to be determined in further studies.
Effects of oral isotretinoin therapy on peripheral nerve functions: A preliminary study. Reply from author
(Oxford, 2008-07) Aydoğan, Kenan; Karlı, Necdet; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; 0000-0002-0193-1128; AAH-6216-2021
Efficacy of low-dose ultraviolet A-1 phototherapy for parapsoriasis/early- stage mycosis fungoides
(Wiley, 2014-01-29) Aydoğan, Kenan; Yazıcı, Serkan; Balaban , Şaduman Adım; Tilki , Işıl Günay; Budak, Ferah Ah; Sarıcaoğlu, Hayriye; Tunalı, Şükran; Bülbül, Emel Başkan; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji ve Venereoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Ünitesi Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı.; 0000-0002-0144-3263; 0000-0001-7625-9148; 0000-0002-0193-1128; AAH-1388-2021; AAH-2459-2021; F-4657-2014; AAH-6216-2021; 9739755800; 25925620000; 14046617400; 56054728500; 6701913697; 6603722836; 7004191748; 6602518817
Mycosis fungoides (MF) and parapsoriasis (PP) are major dermatologic conditions for which phototherapy continues to be a successful and valuable treatment option. UVA-1 phototherapy is effective in the management of cutaneous T-cell mediated diseases. The aim of the study was to evaluate the efficacy and safety of low-dose UVA-1 phototherapy for the management of PP/early-stage MF. A total of 30 patients, diagnosed with MF (n: 19) or PP (n: 11) were enrolled to the study. All patients were managed with low-dose UVA-1 (20 or 30 J cm(-2)). Response was assessed clinically and immunohistochemically. UVA-1 treatment led to clinical and histological complete remission (CR) in 11 of 19 MF patients (57.9%), partial remission (PR) in three of 19 (15.8%), after a mean cumulative dose of 1665 (range, 860-3120) J cm(-2) and mean number of 73 exposure (range, 43-107) sessions. Five patients with PP (45.5%) showed CR, and PR was observed in six patients with PP (54.5%) after a mean cumulative dose of 1723 (range, 1060-3030) J cm(-2) and mean number of 74 exposure (range, 53-101) sessions. We conclude that low-dose UVA-1 therapy seems to be an effective, safe, and well-tolerated treatment option for patients with PP/early-stage MF.
The efficacy of narrowband UVB treatment in pediatric vitiligo: A retrospective analysis of 26 cases
(TÜBİTAK, 2016-03-10) Yazıcı, Serkan; Günay, Berrin; Başkan, Emel Bülbül; Aydoğan, Kenan; Sarıcaoğlu, Hayriye; Tunalı, Şükran; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji ve Venereoloji Anabilim Dalı.; 0000-0001-6407-0962; 0000-0002-0144-3263; AAH-2459-2021; AAH-1388-2021; 25925620000; 57194115820; 6602518817; 9739755800; 6603722836; 7004191748
Background/aim: Narrowband UVB (Nb UVB) treatment is commonly used for the management of psoriasis and atopic dermatitis, and is less often used for vitiligo in children. The aim of this study was to evaluate the efficacy and short-term safety of Nb UVB phototherapy in children diagnosed with vitiligo retrospectively Materials and methods: A total of 26 patients younger than 18 years with the diagnosis of vitiligo and managed with Nb UVB phototherapy as documented in archive records were evaluated. Clinical response was assessed according to repigmentation of the lesions: good response when there was more than 75% repigmentation, moderate response when there was 25%-74% repigmentation, poor response when repigmentation was less than 24%, and unresponsive when there was no pigmentation and new lesions occurred. Results: A total of 26 patients received Nb UVB treatment; 14 were girls and 12 were boys. The age at onset of the disease varied between 2 and 18 years, with a mean age of onset of 10.07 +/- 4.53 years. Repigmentation rate of > 75% was detected in 45.4% of cases. Conclusion: Nb UVB phototherapy seems to be a well-tolerated effective and safe treatment option in children, especially those unresponsive to topical treatment and those with widespread lesions. However, long-term risks such as photocarcinogenesis and photoaging should kept in mind.
Empact syndrome: A case report and review of the literature
(Wiley, 2010-08) Aydoğan, Kenan; Vatansever, Sevgül; Adım, Şaduman Balaban; Sarıcaoğlu, Hayriye; Uludağ Üniversitesi/Tıp Fakültesi/Deri ve Zührevi Hastalıklar Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.; 0000-0002-0193-1128; AAH-6216-2021; 9739755800; 37060067700; 15730076300; 6603722836
Erythema nodosum epidemiology: 5-year retrospective study
(Wolters Kluwer Medknow Publications, 2012-09-01) Öz, Arife; Aydoğan, Kenan; Adım, Saduman Balaban; İzol, Belçin; Sarıcaoğlu, Hayriye; Başkan, Emel Bülbül; Tunalı, Şükran; Öz, Arife; AYDOĞAN, KENAN; BALABAN ADIM, ŞADUMAN; SARICAOĞLU, HAYRİYE; BÜLBÜL BAŞKAN, EMEL; Tunalı, Sükran; Uludağ Üniversitesi/Tıp Fakültesi/Deri ve Zührevi Hastalıklar Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-0144-3263 ; JQC-1664-2023; AAH-6216-2021; EMN-0789-2022; DPU-8534-2022; AAH-1388-2021; GGH-7385-2022
Objective: Erythema nodosum (EN) is the most common type of septal panniculitis. Although triggering factors of EN are drugs, infections, malignancies, inflammatory diseases however disease is idiopathic in 32-72%. Factors are changing from region to region and from country to country. In this study, our aim was to investigate the etiologic factors and to evaluate the clinic and laboratory findings of EN.Methods: Sixty-six patients who were histopathologically diagnosed as EN in our department between 2005 and 2010 were included to this study. Demographic data and treatment were evaluated.Results: Fifty-two of 66 patients had underlying etiologic factors (Group 1) and 14 of were idiopatic (Group 2). Most common etiologic factor was Behcet's disease (n=15), and followed by drug (n=13), sarcoidosis (n=10), upper respiratory tract infection (n=6), autoimmune disease (n=4), pregnancy (n=2), tuberculosis (n=2) in decreasing frequencies. In our study malignancy and inflammatory bowel disease are not appointed.Conclusion: Behcet's disease is a rare cause of EN. In other studies in our country the idiopatic group was in majority. In our study because of finding the common etiologic factor as Behcet's disease due to being of Behcet's disease high prevalance (11-42/10000) in our country and existence of Behcet's disease center in our faculty
Flow cytometric analysis of T, B, and NK cells antigens in patients with mycosis fungoides
(Hindawi, 2015-11-24) Yazıcı, Serkan; Başkan, Emel Bülbül; Budak, Ferah; Oral, Barbaros; Adım, Şaduman Balaban; Kalın, Zübeyde Ceylan; Özkaya, Güven; Aydoğan, Kenan; Sarıcaoğlu, Hayriye; Tunalı, Şükran; YAZİCİ, SERKAN; BÜLBÜL BAŞKAN, EMEL; BUDAK, FERAH; ORAL, HALUK BARBAROS; BALABAN ADIM, ŞADUMAN; Kalın, Zübeyde Ceylan; ÖZKAYA, GÜVEN; AYDOĞAN, KENAN; SARICAOĞLU, HAYRİYE; Tunalı, Şükran; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji ve Zührevi Hastalıklar Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0001-6407-0962; 0000-0001-7625-9148; 0000-0003-0463-6818; 0000-0003-0297-846X; 0000-0002-0193-1128; IZP-9398-2023; AAH-2459-2021; AAH-1388-2021; A-4421-2016; F-4657-2014; AAH-6216-2021; K-7285-2012; EMN-0789-2022; CWV-8710-2022; DPU-8534-2022; GGH-7385-2022
We retrospectively analyzed the clinicopathological correlation and prognostic value of cell surface antigens expressed by peripheral blood mononuclear cells in patients with mycosis fungoides (MF). 121 consecutive MF patients were included in this study. All patients had peripheral blood flow cytometry as part of their first visit. TNMB and histopathological staging of the cases were retrospectively performed in accordance with International Society forCutaneous Lymphomas/European Organization of Research and Treatment of Cancer (ISCL/EORTC) criteria at the time of flow cytometry sampling. To determine prognostic value of cell surface antigens, cases were divided into two groups as stable and progressive disease. 17 flow cytometric analyses of 17 parapsoriasis (PP) and 11 analyses of 11 benign erythrodermic patients were included as control groups. Fluorescent labeled monoclonal antibodies were used to detect cell surface antigens: T cells (CD3(+), CD4(+), CD8(+), TCR alpha beta(+), TCR gamma delta(+), CD7(+), CD4(+) CD7(+), CD4(+) CD7(-), and CD71(+)), B cells (HLA-DR+, CD19(+), and HLA-DR(+)CD19(+)), NKT cells (CD3(+)CD16(+)CD56(+)), and NK cells (CD3(-)CD16(+)CD56(+)). The mean value of all cell surface antigens was not statistically significant between parapsoriasis and MF groups. Along with an increase in cases of MF stage statistically significant difference was found between the mean values of cell surface antigens. Flow cytometric analysis of peripheral blood cell surface antigens in patients with mycosis fungoides may contribute to predicting disease stage and progression.
Hafif ve orta şiddetli akne vulgaris tedavisinde sodyum sulfasetamidin etkinliǧi: Randomize, karşılaştırmalı çalışma
(Türk Dermatoloji Veneroloji Derneği, 2012-03) Turan, Hakan; Turan, Ayşegül; Sancaoğlu, Hayriye; Başkan, Emel Bülbül; Aydoğan, Kenan; Uludaǧ Üniversitesi/Tıp Fakültesi/Deri ve Zührevi Hastalıklar Anabilim Dalı.; 0000-0002-0144-3263; AAH-1388-2021; AAH-6216-2021; 14055302400; 6603722836; 6602518817; 9739755800
Amaç: Hafif ve orta dereceli akne vulgariste en çok kullanılan topikal antibiyotikler klindamisin ve eritromisindir. Topikal antibiyotiklerin benzoil peroksit ile kombinasyonu etkinliği artırır ve Propionibacterium acnes’e karşı gelişen antibiyotik direncini azaltır. Sodyum sulfasetamid sülfonamid grubu bir antibiyotiktir. Uzun yıllardır bilindiği halde akne tedavisinde fazlaca yer almamaktadır. Ancak son zamanlarda kullanımı tekrar gündeme gelmiştir. Çalışmamızda hafif ve orta derecedeki akne vulgariste sodyum sulfasetamidin etkinliğini klindamisin ve eritromisin ile karşılaştırmalı olarak değerlendirmeyi amaçladık. Gereç ve Yöntem: Karşılaştırmalı çalışmamızda akne vulgarisli 60 hasta, birinci grup sodyum sulfasetamid %10 losyon, ikinci grup klindamisin %1 losyon ve üçüncü grup eritromisin %2 jel 12 hafta süre ile günde iki kez uygulamak üzere, randomize olarak 3 gruba ayrıldı. Her grupta 20 olgu yer aldı. Tedavi tüm hastalarda benzoil peroksit %5 losyon ile kombine edildi. Hastalar başlangıçta, 4, 8 ve 12. haftalarda noninflamatuvar (açık ve kapalı komedo) ve inflamatuvar (papül ve püstül) lezyon sayıları açısından değerlendirildi ve yan etki ler kaydedildi. Bulgular: Gruplar arasında yaş, cinsiyet ve akne süresi yönünden anlamlı fark yoktu (p>0,05). Çalışma sonunda her 3 tedavi yöntemi ile de istatistiksel olarak anlamlı azalma saptandı (p<0,05). Noninflamatuvar lezyon sayısı ve total lezyon sayısındaki azalma açısından 4, 8 ve 12. haftalarda her 3 grup arasında anlamlı fark saptanmazken inflamatuvar lezyon sayısındaki azalma açısından 8. haftada klindamisin diğer tedavilere göre daha üstün bulundu (p<0,05). Yan etki görülme oranları açısından da her 3 grup arasında anlamlı fark saptanmadı (p>0,05). Sonuç: Bu çalışmada topikal sodyum sulfasetamidin, hafif ve orta şiddette akne vulgarisin tedavisinde, benzoil peroksitle kombine kullanıldığında klindamisin ve eritromisin gibi etkili ve güvenilir olduğu sonucuna varılmıştır. Bu sonuç daha geniş olgu sayılı çalışmalarla desteklenmelidir.
HLA class I and class II antigens in Turkish patients with chronic ordinary urticaria
(Dermatology, 2006) Aydoğan, Kenan; Karadoğan, Serap Köran; Akdağ, İhsan Ömür; Tunalı, Şükran; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0193-1128; AAH-6216-2021; 9739755800; 9738885800; 8342488100; 7004191748
Background. Chronic urticaria is a common disease with an unclear pathogenesis, which may be resistant to therapy. Recent studies have focused primarily on a possible autoimmune basis. Aim. To investigate HLA class I and II antigens in a Turkish population with chronic ordinary urticaria (COU; not physical, vasculitic or contact), and identify susceptible HLA antigens. Methods. HLA antigens were investigated in 55 patients diagnosed with COU, using a two-stage microdroplet lymphocytotoxicity test, with 104 healthy and genetically unrelated individuals evaluated as the control group. Results. HLA Bw4 and HLA DQ1 antigens were significantly higher in the study group (odds ratio (OR) = 2.93, 95% CI 1.47-5.85, P = 0.003 and OR = 7.81, 95% CI 1.96-28.50, P = 0.001, respectively) whereas HLA-A24 antigen was higher in controls (OR = 0.36, 95% CI 0.15-0.86, P = 0.03). Conclusion. We propose that HLA-Bw4 and DQ1 antigens may be responsible for susceptibility to COU while HLA-A24 may have a protective role in the Turkish population.