Browsing by Author "Zorluoğlu, Abdullah"
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Item 112 Mide kanserli olgunun analizi(Uludağ Üniversitesi, 1991) Yılmazlar, Tuncay; Zorluoğlu, Abdullah; Karagöz, Cengiz; Kızıl, Ayhan; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.Uludağ Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalında Man 1983-Aralık 1989 (6 yıl 10 ay) tarihleri arasında cerrahi girişim uygulanan histopatolojik olarak tanısı konmuş 112 mide kanserli (adenokarsinom) hasta retrospektif olarak incelenmiştir Olguların 52'si (%46.4) rezektabl geri kalan 60'ının (% 53.6) non rezektabl olduğu saptanmıştır. Rezektabl olguların % 62'sine küratif rezeksiyon, kalan % 38'ine palyatif rezeksiyon uygulanmıştır. Non Rezektabl olgulara çeşitli palyatif girişimler uygulanmıştır. Yaşam süresi küratif rezeksiyon yapılanlarda 4 ay - 4.5 yıl, palyatif rezeksiyon yapılanlarda 3-14 ay arasındadır. Palyatif girişim uygulanan non rezektabl olgular postoperatif ilk 5 ayda ölmüşlerdir. Sonuç olarak; rezektabl mide kanserinde, palyatif amaçlı bile olsa rezeksiyonun olabildiğince geniş tutulmasına çaba gösterilmesinin yaşam süresine olumlu katkıda bulunacağı yargısına varılmıştır.Item Alterations of MiRNA expression in early-onset Turkish colorectal cancer patients' tumor tissues(Elsevier, 2012-07) Zorluoğlu, Abdullah; Ak, Seçil; Tunca, Berrin; Çeçener, Gülşah; Egeli, Ünal; Tezcan, Gülçin; Yılmazlar, Tuncay; Öztürk, Elif; Yerci, Ömer; Evrensel, Türkkan; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.; 0000-0002-1619-6680; 0000-0002-9732-5340; F-8554-2017; ABI-6078-2020; AAH-3843-2020; AAH-3847-2021; AAJ-1027-2021Item Analysis of mismatch repair gene mutations in Turkish HNPCC patients(Springer, 2010-09) Pedroni, Monica; Borsi, Enrica; Zorluoğlu, Abdullah; Di Gregoria, Carmela; Ponz de Leon, Maurizio; Tunca, Berrin; Çeçener, Gülşah; Egeli, Ünal; Yılmazlar, Tuncay; Yerci, Ömer; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.; 0000-0001-7904-883X; 0000-0002-1619-6680; 0000-0002-3820-424X; AAH-1420-2021; ABI-6078-2020; AAP-9988-2020; 6602965754; 6508156530; 55665145000; 6701800362; 6603810549Hereditary non-polyposis colorectal cancer (HNPCC or Lynch syndrome) is caused by the inheritance of a mutant allele of a DNA mismatch repair gene. We aimed to investigate types and frequencies of mismatch repair (MMR) gene mutations in Turkish patients with HNPCC and to identify specific biomarkers for early diagnosis of their non-symptomatic kindred's. The molecular characteristics of 28 Turkish colorectal cancer patients at high-risk for HNPCC were investigated by analysis of microsatellite instability (MSI), immunohistochemistry and methylation-specific PCR in order to select tumors for mutation analysis. Ten cases (35.7%) were classified as MSI (+). Lack of expression of the main MMR proteins was observed in MSI (+) tumors. Hypermethylation of the MLH1 promoter region was observed in one tumor. Nine Lynch syndrome cases showed novel germ-line alterations of the MMR gene: two frame-shifts (MLH1 c.1843dupC and MLH1 c.1743delG) and three missense mutations (MLH1 c.293G > C, MLH1 c.954_955delinsTA and MSH2 c.2210G > A). Unclassified variants were evaluated as likely to be pathogenic by using the in-silico analyses. In addition, the MSH2 c.2210G > A alteration could be considered as a founder mutation for the Turkish population due to its identification in five different Lynch syndrome families and absence in control group. The present study adds new information about MMR gene mutation types and their role in Lynch syndrome. This is the first detailed research on Turkish Lynch syndrome families.Item Analysis of prognostic and immunohistochemical factors in gastrointestinal stromal tumors with malignant potential(Springer, 2005-03-03) Özgüç, Halil; Yılmazlar, Tuncay; Yerci, Ömer; Soylu, Ruşen; Tümay, Volkan; Filiz, Gülaydan; Zorluoğlu, Abdullah; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.; 0000-0002-6206-9332; A-2109-2019; 6603867989; 6701800362; 6603810549; 8273691000; 6504528797; 6602693514; 6602076843The aim of this study was to analyze 37 patients with malignant primary gastrointestinal stromal tumors and to compare the findings and their therapeutic implications with those previously reported. The medical records of 37 patients who were diagnosed and operated on between January 1996 and December 2002 were retrospectively reviewed. The patients' age, tumor size, type of surgery, histologic type, mitotic counts, presence of necrosis, Ki-67 proliferative index, National Institutes of Health 2001 consensus classification, immunohistochemical staining, and recurrence were examined to analyze factors affecting survival. Overall actuarial survival for all patients was 46%. When analyzed by type of resection, the complete resection group (R0 resection) had a mean overall survival of 48.2 +/- 6.18 months compared with the patients with incomplete resection (R1-R2) who survived a mean of 10.8 +/- 3.2 months (P = 0.00). Univariate analysis showed development of recurrence (P = 0.00), tumor size of 8 cm or greater (P = 0.05), Ki-67 proliferative index greater than 0.82 (P = 0.0448), desmin staining (P = 0.0076), age younger than 49 years (P = 0.0009), and incomplete resection (P = 0.00) to be significantly correlated with a poor survival. In multivariate analysis, desmin staining (P = 0.031), tumor size (P = 0.033), age (P = 0.01), recurrence (P = 0.038), and R0 resection (P = 0.02) were significant independent prognostic factors. We recommend that more careful preoperative and more frequent postoperative follow-up examinations be performed for patients with large tumors, age of younger than 49 years, and Ki-67 proliferative index greater than 0.82.Item Colorectal cancer in young adults(Casa Editrice Ambrosiana, 1995-07-01) Yılmazlar, Tuncay; Zorluoğlu, Abdullah; Özgüç, Halil; Korun, Nusret; Duman, Hakan; Kaya, Ekrem; Kızıl, Ayhan; Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-9562-4195; AAG-7319-2021The study was carried out to promote a greater awareness of the potential for colorectal cancer in young adults under 40 years of age. During the 8 years between 1986 and 1993, 237 patients with adenocarcinoma of the colon and rectum were operated at the Uludag University Hospital. Of these 237 cases, 46 patients under 40 years old were reviewed retrospectively. They accounted for 19.4% of the total number of patients with carcinoma of the colon and rectum operated during the same period. Rectal bleeding was the most common presenting symptom. The mean duration of time from the onset of symptoms to diagnosis was 5.8 months. The rectosigmoid area was the most frequently involved site (80%). Seventy-six percent of the patients had Dukes' stage C or D tumors. Forty-eight percent of the tumors were either poorly differentiated or mucinous. The cumulative survival rate at 5 years was 43.4%. Patients under 40 years old with carcinoma of the colon and rectum are usually symptomatic and have advanced disease at the time of presentation. Although colorectal cancer is usually a disease of older patients it is becoming more common in younger populations.Item Elektif kolesistektomilerde drenajın yeri(Uludağ Üniversitesi, 1992) Yılmazlar, Tuncay; Zorluoğlu, Abdullah; Güneş, İlknur; Kızıl, Ayhan; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nükleer Tıp Anabilim Dalı.Uludağ Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalında 35 elektif kolesistektomi olgusunda prospektif bir çalışma ile safra sızıntısını görüntülemek için kolesintigrafi yöntemi uygulanarak rutin dren kullanımının gerekliliği araştırıldı. Bu amaçla olgular operasyondaki safra sızıntısı veya şüphesine göre dren gerektiren 10 olgu (Grup I); safra sızıntısı veya şüphesi olmayan drenli 10 olgu (Grup Il) ve drensiz 15 olgu (Grup lll) olmak üzere 3 grupta ele alındı. Sintigrafik olarak toplam % 15'inde safra sızıntısı saptanan olgularımızın asemptomatik seyretti. Kolesistektomi sonrası meydana gelen safra sızıntısının çoğu kez sorunsuz kaldığı, bu nedenle komplike olmayan elektif kolesistektomilerde rutin drenajın gereksiz olduğu sonucuna varıldı.Item Elektif kolon operasyonlarında sistemik seftriakson-ornidazol kombinasyonu profilaksisi(Uludağ Üniversitesi, 1992) Yılmazlar, Tuncay; Zorluoğlu, Abdullah; Duman, Hakan; Akbulut, Erol; Kızıl, Ayhan; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.Uludağ Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalında 1991 yılında (12 ay) değişik kolon-rektum patolojisi nedeni ile yatırılan 38 olguda; 3 günlük klasik barsak hazırlığı takiben preop, postop 12. ve 24. saatlerde (3 doz) olmak üzere Seftriakson (I gr) + Omidazol (0.5 gr) kombinasyonu (IV) sistemik profilaksi amacıyla uygulanmıştır. Toplam 3 olguda (% 7.8) yara enfeksiyonu gelişmiştir. Sonuç olarak; kolon cerrahisinde seftriakson-omidazol kombinasyonunun, uygun kemoprofilaktik ajanlar olduğu kanısına varılmıştır.Item Erişkinde outpatient herniorafi(Uludağ Üniversitesi, 1988) Zorluoğlu, Abdullah; Bozgül, Mustafa; Özyurt, Gürayten; Kızıl, Ayhan; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.Uludağ Üniversitesi Tıp Fakültesi Genel Cerrahi Ana Bilim Dalında Haziran 1985-Nisan 1987 tarihleri arasında (23 ay) 50 erişkin olguya outpatient olarak herniorafi uygulanmıştır . Outpatient grupta postoperatif komplikasyon; 2 olguda yara infeksiyonu, 1 olguda nüks olarak (gerçek nüks olmayıp gözden kaçmış bir indirekt herni) saptanmıştır. İnpatient 10 olguda yara infeksizyonu 2 olguda görülmüş ve 4-18 aylık takipte nüks saptanmamıştır. Outpatient olarak planlanıp inpatient gruba transfer olan olgu ayısı 2'dir (% 4). Yazıda erişkin tip inguinal ve femoral hernilerde outpatient herniorafi uygulamasının (lokal anestezi) ekonomik yönden % 43 daha ucuz olduğu ve post op. komplikasyonlar yönünden belirgin bir fark olmadığı vurgulandı ve bu konuda literatür verileri gözden geçirildi.Item Erken relaparatomilerin mortaliteyle ilişkisi(Uludağ Üniversitesi, 1988) Zorluoğlu, Abdullah; Tıkız, Nedim; Taşdelen, İsmet; Kızıl, Ayhan; Şahin, Baki; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.Uludağ Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalında Ocak 1984-Aralık 1986 tarihleri arasında (36 ay) çeşitli nedenlerle 2538 primer laparatomi yapılmış ve bunlardan 51 olguya erken post operatif devrede (post 0 -21 gün) relaparatomi yapılmıştır (42 olguya 1 kez, 7 olguya 2 kez ve 2 olguya 4 kez). Böylece relaparatomi oranı % 2 'dir. Mortalite oranı 13/51 (% 25) tir. Fatal sonlanan olguların 11'inde relaparatomi nedeni intra abdominal sepsis, 2'sinde evisserasyondur. Bu yazıda relaparatomi nedenleri ile mortalite arasındaki ilişki araştırılmış ve literatür verileriyle karşılaştırılmıştır.Item The expression frequency of common fragile sites and genetic predisposition to colon cancer(Elsevier Science, 2000) Tunca, Berrin; Egeli, Ünal; Zorluoğlu, Abdullah; Yılmazlar, Tuncay; Yerci, Ömer; Kızıl, Ayhan; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-1619-6680; ABI-6078-2020The expression frequency of common fragile sites induced by aphidicolin (Apc), bromodeoxyuridine (BrdU), and caffeine was evaluated on prometaphase chromosomes obtained from the peripheral blood lymphocytes of 32 patients with colon cancer, 30 of their clinically healthy family members and 30 age-matched normal controls. The proportion of-damaged cells (P < 0.001), the mean number of chromosomal aberrations and the expression frequencies of fragile sites were significantly higher in the patient and relative groups compared to the control group. Our findings show an increased genetic instability in patients with colon cancer and their first-degree relatives. In addition, common fragile sites can be used as a suitable marker for determining genetic predisposition to cancer.Item The expression of fragile sites in lymphocytes of patients with rectum cancer and their first-degree relatives(Elsevier Sci Ireland, 2000-05-01) Tunca, Berrin; Egeli, Ünal; Zorluoğlu, Abdullah; Yılmazlar, Tuncay; Yerci, Ömer; Kızıl, Ayhan; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.; 0000-0002-1619-6680; ABI-6078-2020Fragile sites are non-staining gaps and breaks in specific points of chromosomes. These sites also include acentric fragments, triradial figures and several rearrangements. Although this issue has been controversial recently, they may be related to structural chromosomal rearrangement in some neoplasms. In this study, the expression of fragile sites induced by aphidicolin (Apc), 5-bromodeoxyuridine (BrJU) and caffeine was investigated on prometaphase chromosomes obtained from the peripheral blood lymphocytes of 36 patients with rectum cancer, 30 first-degree relatives and 30 normal healthy controls. The results of the structural chromosome aberrations determined in patients and their first-degree relatives were significantly higher than those in control subjects (P < 0.001). We determined aphidicolin type common fragile sites (1p36, 1p31, 1p21, 1q21, 1q25, 1q44, 2p24, 2q21, 2q33, 2q37, 3p14, 5q21, 5q33, 13q13, 14q24, 16q23 and 18q21). When the rates of sites such as 1p21, 1q25, 2q33, 3p14, 5q21 and 14q24 in patients and in their first-degree relatives were compared with the control group, the difference was statistically significant. Our results indicated an increased genetic instability in patients with rectum cancer and their first degree relatives. Therefore, the increase of fragile site expression may be an important marker showing genetic predisposition to rectum cancer.Item Factors affecting the prognosis of patients with colorectal liver metastasis(Taylor & Francis, 2010-04) Öztürk, Ersin; Kılıçturgay, Sadık; Yılmazlar, Tuncay; Zorluoğlu, Abdullah; Özen, Yılmaz; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; 35070171400; 6603131340; 6701800362; 6602076843; 6508243334Purpose : To determine factors affecting the survival of colorectal cancer patients developing liver metastasis. Material and methods : 850 colorectal cancer patients who had been operated on between 1995 and 2005 were retrospectively reviewed and patients who developed liver metastases were selected. Patients' demographics and data regarding the characteristics and management of primary tumors and liver metastases were assessed. Survival data were analyzed using Cox proportional hazard method to identify factors affecting prognosis of such patients. Results : 154 (18.1%) patients developed liver metastasis; however, only 60 patients (39 males and 21 females; median age : 61 (31-77) years) had complete follow-up data, of whom 28 had undergone metastasis resection. The median survival time of patients who underwent resection and who did not was 42 (22-118) vs. 13 (2-52) months (p < 0.001). Curative resection of the primary tumor (p = 0.32; Exp(B) = 2.93), metastases that were less than 5 in number and localized to one of the right or left lobes (p = 0.004; Exp(B) = 3.38), and surgical resection of the metastases (p = 0.001; Exp(B) = 3.76) were independent risk factors. Conclusions : Patients with colorectal liver metastases that are less than 5 and confined into one lobe, could benefit from metastasis surgery most if the primary tumor is resected.Item Gastric metastasis of signet ring cell carcinoma of the breast(Saudi Medical Journal, 2006-02) Çetintaş, Sibel Kahraman; Kurt, Meral; Özkan, Lütfi; Yerci, Ömer; Zorluoğlu, Abdullah; Turan-Özdemir, Senem; Engin, Kayıhan; Gürel, Selim; Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.; 0000-0003-1637-910X; AAA-3961-2020; AAA-7047-2020; AAA-8734-2021; 6505881756; 8843050600; 55915679400; 6603810549; 6602076843; 18038353400; 6701768798; 7003706434Item High expression of multidrug resistance-1 (MDR-1) and its relationship with multiple prognostic factors in gastric carcinomas in patients in Turkey(Cambridge Med Publ, 1999) Gürel, Selim; Yerci, Ömer; Filiz, Gülaydan; Dolar, Mahmut Enver; Yılmazlar, Tuncay; Nak, Selim Giray; Gülten, Macit; Zorluoğlu, Abdullah; Memik, Faruk; Uludağ Üniversitesi/Tıp fakültesi/Gastroenteroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; AAG-9177-2021Drug resistance remains a major problem in the treatment of gastric cancer. In Turkey, gastric carcinoma is the second most common cancer and, because the rate of early diagnosis is low, chemotherapy plays an important role in the treatment of the disease. We aimed to investigate expression of the multidrug resistance-1 gene (MDR-1) and its relationship with multiple prognostic factors in gastric cancers. Between 1996 and 1998, a total of 55 patients (37 men and 19 women; median age 55 years) were studied. Sections from specimens of gastric carcinomas were immunohistochemically stained to detect P-glycoprotein (which is associated with MDR-1 expression). We found MDR-1 expression in 48 (87%) of the patients. None of the multiple prognostic factors, including histological type of tumour, correlated with expression of MDR-1. Patients who had low MDR-1 expression had better survival. We conclude that the expression of MDR-1 in gastric cancer is high in Turkey, and this may be related to poor prognosis.Item Ideal combination of MRI sequences for perianal fistula classification and the evaluation of additional findings for readers with varying levels of experience(AVES, 2012-01) Yıldırım, Nalan; Gökalp, Gökhan; Öztürk, Ersin; Zorluoğlu, Abdullah; Yılmazlar, Tuncay; Ercan, İlker; Savcı, Gürsel; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-2382-290X; AAH-5481-2021; AAI-2336-2021; 36867883100; 8312505100; 35070171400; 6602076843; 6701800362; 6603789069; 6603625971PURPOSE: The aim of our study was to assess the contribution of various magnetic resonance imaging (MRI) sequences in determining the type of perianal fistula and in obtaining critical information for surgical decisions, as well as to define the optimal combination of sequences for readers with varying levels of experience. MATERIALS AND METHODS: The study included 33 MRI examinations in 26 patients with suspected perianal fistula. The following sequences were obtained in both the coronal and axial planes: thin slice, high resolution T1-weighted (W) spin echo; T2-weighted turbo spin echo; short tau inversion recovery (STIR); and native and contrast enhanced T1 -weighted gradient echo fast low-angle shot (FLASH) images with fat suppression (FS-CE-T1W-GRE). The examinations were interpreted by three radiologists with varying degrees of experience in two different sessions, and the inter-reader agreement was assessed. Seventeen of the patients underwent surgery. The agreement between the surgical findings and the MRI results were evaluated. RESULTS: A statistically significant concordance between the fistula classification and surgery was achieved with the FS-CE-T1W-GRE sequence for Reader 1 (Cramer's V=0.701, P = 0,022) and Reader 3 (Cramer's V=0.716, P = 0,043). For Reader 2, statistically significant concordance between fistula classification and surgery was achieved with the FS-CE-T1W-GRE (Cramer's V=0.703, P = 0,011) and the T2W images (Cramer's V=0.648, P = 0,027). For all sequences, there was statistically significant agreement between readers for fistula classification, internal opening location, and the presence of sinus tracts, abscess, a horseshoe component, and inflammation. CONCLUSION: For experienced readers, combining FS-CE-T1W-GRE images with either T2W or STIR images collected in both the coronal and axial planes was sufficient to make an assessment before deciding the surgical extent of the procedure.Item İnsülinoma(Uludağ Üniversitesi, 1988) Zorluoğlu, Abdullah; İmamoğlu, Şazi; Kızıl, Ayhan; Tolunay, Şahsine; Özen, Yılmaz; Yılmazlar, Tuncay; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.Uludağ Üniversitesi Tıp Fakültesi Endokrinoloji kliniğince tanısı konan ve Cerrahi Kliniğinde ameliyat edilen, 9 yıldan beri hipoglisemik ataklarla seyreden bir insulinoma olgusu, nadir görülmesi ve tanı güçlükleri nedeniyle ilgili literatür gözden geçirilerek sunulmuştur.Item Is it necessary to retrieve dropped gallstones during laparoscopic cholecystectomy?(Springer, 1997) Zorluoğlu, Abdullah; Özgüç, Halil; Yılmazlar, Tuncay; Güney, Nejat; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Acil Tıp ve Travma Merkezi; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Cerrahisi Anabilim Dalı.Background: An experimental study was planned to evaluate the effect of bile alone and bile in combination with gallstones on intraperitoneal adhesion and abscess formation in the peritoneal cavity of the rat, Methods: One hundred Sprague-Dawley rats were assigned to ten groups (n: 10). Groups 1-3 received a 1-ml intraperitoneal injection of saline, sterile bile, and infected bile, Groups 4-10 underwent a lower 5-mm midline abdominal incision, In groups 5, 7, and 9, a single gallstone (3-mm diameter) was placed in the right upper quadrant and injected with sterile saline, sterile bile, and infected bile, respectively. In groups 6, 8, and 10, four gallstones (3-mm diameter) were placed in the right upper quadrant together with sterile saline, sterile bile, and infected bile, respectively, Group 4 only underwent a 5-mm midline incision, All animals were sacrificed at the end of 4 weeks and the peritoneal cavity was carefully examined to investigate adhesions and abscess formation, The adhesions were graded according to Nair's gross pathologic grading of adhesions. The Kruskal-Wallis nonparametric test (KW) was used for statistical analysis. Results: No intraabdominal lesions were noted in groups 1-3, The adhesion score was increased by number of scene and infected bile (G4: 3, G5: 3, 66: 11, G7: 7, G8: 10, G9: 15, G10: 18), But there was only a significant difference between the groups that received sterile saline + single stone (G5) and that receiving infected bile + four stones (G10) (KW: 24.3 P < 0.05), There was abscess formation in three rats in group 9 and two in group 10, Conclusions: In conclusion, infected bile in combination with multiple stones increases the gross grading of adhesion and intraabdominal abscess formation, Thus, in cases with multiple stones and infected bile, the dropped stones should be retrieved and the peritonial cavity should be copiously irrigated during laparoscopic cholecystectomy.Item Karaciğer kist hidatiği(Uludağ Üniversitesi, 1988) Kutlay, Burçin; Zorluoğlu, Abdullah; Özen, Yılmaz; Karagöz, Ömer; Kızıl, Ayhan; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.Uludağ Üniversitesi Tıp Fakültesi Genel Cerrahi Kliniğinde 1977-1987 yılları arasında karaciğer kist hidatiği nedeniyle cerrahi tedavi uygulanan 64 hasta retrospektif olarak incelendi ve 8 ay-6 yıllık takip sonuçları değerlendirildi. Yaşları 15 ile 75 arasında değişen olguların 39 'u kadın, 25 'i erkekti. Uygulanan cerrahi girişimler; 6 olguda total kistektomi, 49 olguda parsiyel kistektomi + intrafleksiyon + omentoplasti, 7 olguda kapalı drenaj ve 2 olguda marsupializasyondur. Postoperatif 8 ay-6 yıllık takibi yapılan 34 hastada geç komplikasyon olarak 8 abse formasyonu (% 12,5), 2 safra fistülü (% 5,5) ve 6 nüks kist hidatik"(% 17,5) tesbit edilmiştir.Item Karaciğer yaralanmaları(Uludağ Üniversitesi, 1988) Özen, Yılmaz; Zorluoğlu, Abdullah; Balkan, Emine; Kızıl, Ayhan; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.1 Ocak 1984 · 31 Eylül 1987 tarihleri arasında (45 ay) Uludağ Üniversitesi Tıp Fakültesi Genel Cerrahi Ana Bilim Dalı'nda karaciğer yaralanması nedeniyle cerrahi girişim uygulanan 73 olgu retrospektif olarak incelendi. Olguların 56 'sı erkek , 17'si kadın olup yaşları 4 ·75 arasındadır (Ortalama yaş 36). Yaralanma şekli 51 olguda künt, 22 olguda penetran olup en sık görülen etken trafik kazalarıdır (% 62). Olguların 11'inde izole karaciğer yaralanması saptanmıştır. Cerrahi tedavi yöntemleri olarak 64 olguda primer sütür onarımı, drenaj, 7 olguda Mikulicz tamponad, 1 olguda eksizyonel debridman ve 1 olguda parsiyel hepatektomi uygulandı. Mortalile oranı % 17.8 (izole karaciğer yaralanmalarında % 5.9, yandaş organ yaralanması da bulunanlarda % 11.9), morbidite oranı % 22 (izole karaciğer yaralanmalarında % 6. 7, yandaş organ yaralanmalı olgularda % 15. 3) olmuştur. Hastanede ortalama kalış süresi 11.3 gün olmuştur.Item Koleslstektomili olguların postoperatif safra sızıntısı yönünden hepatobilier sintigrafi ile değerlendirilmesi(Uludağ Üniversitesi, 1990) Güneş, İlknur; Yılmazlar, Tuncay; Zorluoğlu, Abdullah; Kızıl, Ayhan; Uludağ Üniversitesi/Tıp Fakültesi/Nükleer Tıp Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.Elektif kolesistektomi uygulanan 35 olguda postoperalif 1. gün Tc 99m-IDA ile hepatobilier sintigrafi (kolesintigrafi) çalışması yapıldı. Kolesintigrafi ile postoperatif safra sızıntısı, bilier obstrüksiyon ve hepatosellüler disfonksiyon bulguları değerlendirildi. Safra sızıntısının sık görülen bir komplikasyon olduğu ve basit ve non-invaziv bir metod olan kolesintigrafi ile kolayca saptanabileceği belirlendi. % 15 oranında saptanan safra sızıntısının olguların hepsinde fokal ve az miktarda olup asemptomatik seyrettiği görüldü. Çalışma sonunda elde edilen bulgular literatür ile uyumlu bulundu.
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