Person: ÖZARDA, YEŞİM
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Publication Stability of hematological analytes during 48 hours storage at three temperatures using cell-dyn hematology analyzer(Soc Medical Biochemists Serbia, 2021-01-01) Özmen, Sevda Ünalli; Özarda, Yeşim; ÖZARDA, YEŞİM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı; AAL-8873-2021Background: The complete blood count (CBC) with differential leukocyte count (DLC) is one of the most common tests requested by physicians. The results of this test are affected by storage temperature and time of incubation. This study was designed to evaluate the stability of hematologic parameters in blood specimens stored for 48 h at three temperatures.Methods: K-2-EDTA - blood was collected from 22 healthy adults. The CBC was performed using a hematology analyser immediately; 0 time point and at 4, 8, 12, 16, 20, 24, and 48 h after storage at 4 degrees C, 10 degrees C or 23 degrees C. Changes in values of CBC parameters from the 0 time point were determined and reported as % of the initial value.Results: Red blood cells, platelet, hemoglobin, and mean corpuscular hemoglobin were found stable during 48 h storage at 4 degrees C, 10 degrees C or 23 degrees C. Hematocrite and mean corpuscular volume increased, while white blood cells decreased at 48 h when stored at 23 degrees C. Lymphocytes, neutrophils, eosinophils, and basophils showed significant differences after 12 h of storage at 23 degrees C.Conclusions: Red blood cells, platelet, hemoglobin, and mean corpuscular hemoglobin are the only suitable parameters without refrigeration during 24 h storage. When CBC and DLC are performed, 4 degrees C can be recommended as the most suitable storage temperature for 12 h storage.Publication Relationship with excessive daytime sleepiness and serum substance P levels in OSAS patients and the effect of PAP treatment(Springer Japan, 2019-07-01) Güçlu, Özge Aydın; Ursavaş, Ahmet; Kasapoğlu, Fikret; Özarda, Yeşim; Bozyiğit, Cengiz; Ocakoğlu, Gökhan; Karadağ, Mehmet; AYDIN GÜÇLÜ, ÖZGE; URSAVAŞ, AHMET; KASAPOĞLU, FİKRET; ÖZARDA, YEŞİM; BOZYİĞİT, CENGİZ; OCAKOĞLU, GÖKHAN; KARADAĞ, MEHMET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0003-1005-3205; 0000-0003-2215-6973; 0000-0002-1114-6051; 0000-0002-9027-1132; AAI-3877-2021; AAI-3169-2021; AAH-5180-2021; AAL-8873-2021; HLG-6346-2023; AAG-8744-2021; AAG-9930-2019; AAE-1623-2022Obstructive sleep apnea syndrome (OSAS) is a commonly seen disorder characterized by repeated episodes of upper airway obstruction during sleep leading to intermittent hypoxemia or arousal. We aim to evaluate the effects of positive airway pressure (PAP) treatment on daytime sleepiness and serum Substance P (SP) levels in OSAS patients. Seventy-one consecutive patients with newly diagnosed OSAS and 19 non-apneic control subjects were enrolled to the study. PAP treatment indicated subjects were re-evaluated after 3 months of treatment. Morning SP levels of OSAS patients and Epworth sleepiness scale (ESS) were assessed at the beginning and then after 3 months of PAP treatment. Of the patients 71 (78.9%) were male and 19 (21.1%) were female, with a median age of 45 [20-62]. The levels of SP in the OSAS group were significantly lower than the snorer group and a significant correlation was not found between serum levels of SP and ESS. SP levels were negatively correlated with AHI. The baseline SP median was 336.1pg/mL [121.6-536.1], while the 3rd month SP median was 213.1pg/mL [103.5-727.6]. Serum SP values were found to have significantly decreased at 3months (p<0.0001). Statistically significant correlation was not found between percentage of ESS change and the percentage of SP change. It can be assumed that the SP level is reduced as part of the compensation mechanism in OSAS cases and supporting this mechanism, the PAP therapy further reduces the SP value by relieving the cases from apnea and the intermittent hypoxia burden.Publication Serum leptin and ghrelin levels and their relationship with serum cortisol,thyroid hormones, lipids, homocysteine and folic acid in dogs with compulsive tail chasing(Cabi Publishing-c A B Int, 2017-01-01) Yalçın, Ebru; Yılmaz, Zeki; Özarda, Yeşim; Denenberg, S; YALÇIN, EBRU; YILMAZ, ZEKİ; ÖZARDA, YEŞİM; Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Bölümü; Denenberg, S; 0000-0001-9836-0749; 0000-0002-6697-6079; AAL-8873-2021; ACP-9956-2022; A-9637-2008Publication A multicenter nationwide reference intervals study for common biochemical analytes in turkey using abbott analyzers(Walter De Gruyter Gmbh, 2014-12-01) Ichihara, Kiyoshi; Aslan, Diler; Aybek, Hulya; Ari, Zeki; Taneli, Fatma; Coker, Canan; Akan, Pinar; Şişman, Ali Riza; Bahçeci, Onur; Sezgin, Nurzen; Demir, Meltem; Yücel, Gultekin; Akbas, Halide; Özdem, Sebahat; Polat, Gürbüz; Erbağci, Ayse Binnur; Örkmez, Mustafa; Mete, Nuriye; Evliyaoglu, Osman; Kıyıcı, Aysel; Vatansev, Hüsamettin; Ozturk, Bahadir; Yucel, Dogan; Kayaalp, Damla; Dogan, Kubra; Pinar, Asli; Gurbilek, Mehmet; Çetinkaya, Çiğdem Damla; Akın, Okhan; Serdar, Muhittin; Kurt, Ismail; Erdinç, Selda; Kadiceşme, Özgur; Ilhan, Necip; Atali, Dilek Sadak; Bakan, Ebubekir; Polat, Harun; Noyan, Tevfik; Can, Murat; Bedir, Abdulkerim; Okuyucu, Ali; Değer, Orhan; Agaç, Suret; Ademoğlu, Evin; Kaya, Aysem; Nogay, Turkan; Eren, Nezaket; Gunes, Yeliz; Kawano, Reo; Tezcan, Sehavet; Demirpençe, Özlem; Değirmen, Elif; Özarda, Yesim; ÖZARDA, YEŞİM; Dirican, Melahat; DİRİCAN, MELEHAT; Tuncer, Gül Özlem; Aykuş, Mehmet; Özmen, Sevda Ünalli; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; KYR-0994-2024; AAL-8873-2021Background: A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and to explore sources of variation in reference values, including regionality.Methods: Blood samples were collected nationwide in 28 laboratories from the seven regions (>= 400 samples/region, 3066 in all). The sera were collectively analyzed in Uludag University in Bursa using Abbott reagents and analyzer. Reference materials were used for standardization of test results. After secondary exclusion using the latent abnormal values exclusion method, RIs were derived by a parametric method employing the modified Box-Cox formula and compared with the RIs by the non-parametric method. Three-level nested ANOVA was used to evaluate variations among sexes, ages and regions. Associations between test results and age, body mass index (BMI) and region were determined by multiple regression analysis (MRA).Results: By ANOVA, differences of reference values among seven regions were significant in none of the 25 analytes. Significant sex-related and age-related differences were observed for 10 and seven analytes, respectively. MRA revealed BMI-related changes in results for uric acid, glucose, triglycerides, high-density lipoprotein (HDL)-cholesterol, alanine aminotransferase, and.-glutamyltransferase. Their RIs were thus derived by applying stricter criteria excluding individuals with BMI >28 kg/m(2). Ranges of RIs by non-parametric method were wider than those by parametric method especially for those analytes affected by BMI.Conclusions: With the lack of regional differences and the well-standardized status of test results, the RIs derived from this nationwide study can be used for the entire Turkish population.