Person: KARACA, ESRA
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KARACA
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ESRA
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Publication Evaluation of Nigella sativa oil loaded electrospun polyurethane nanofibrous mat as wound dressing(Taylor, 2021-06-02) Aras, Cansu; Özer, Elif Tümay; Göktalay, Gökhan; Saat, Gülbahar; Karaca, Esra; ARAS GÜL, CANSU; TÜMAY ÖZER, ELİF; GÖKTALAY, GÖKHAN; KARACA, ESRA; Tıp Fakültesi; Farmakoloji Ana Bilim Dalı; 0000-0003-1777-3977; AAI-3137-2021; AAS-8480-2020; EKA-8835-2022; AAI-3137-2021; JKY-1522-2023; DPL-6507-2022Electrospun nanofibers have a natural wound healing effect due to their similarity to the extracellular matrix (ECM). Nigella sativa oil, which has therapeutic properties, is used for a wide variety of applications in traditional medicine. The aim of this study was to investigate the release characteristic and wound healing performance of Nigella sativa oil (NSO) loaded polyurethane (PU) electrospun nanofibrous mats in wound dressing applications. In addition, the antibacterial activity and cytotoxicity of the electrospun mats were studied. Analyses using a scanning electron microscope (SEM) showed that PU/NSO nanofibrous mat with an average fiber diameter of 416 +/- 66 nm were successfully fabricated. NSO was released at a maximum ratio of 30% from the electrospun mat, and the Korsmeyer-Peppas model was identified as best for determining the release mechanism. Significant antibacterial activity was observed against Staphylococcus aureus (90.26%) and Escherichia coli (95.75%). The developed PU/NSO nanofibrous mat increased the cell viability more than 100% in human umbilical vein endothelial cell line (HUVEC) cell line. The NSO loaded PU nanofibrous mat significantly promoted the wound healing process on a rat wound model, and its wound closure reached approximately 85% compared to the control groups on the 9(th) day (p < 0.01). The results indicated PU/NSO nanofibrous mat is a suitable candidate for a wound dressing.Publication Dyeing and some fastness properties of novel perlite-containing polyester woven fabrics(Sage Publications Inc, 2022-03-01) Becerir, Behcet; BECERİR, BEHÇET; ÖMEROĞLU, SUNAY; Karaca, Esra; KARACA, ESRA; Mühendislik Fakültesi; Tekstil Mühendisliği Bölümü; 0000-0002-2655-2773; 0000-0003-1777-3977; AAS-8480-2020; AAH-1445-2021This article is focused on the comparison of dyeing, and washing and light fastness properties of conventional and novel perlite-containing polyester woven fabrics via color measurements. All the production processes for the regular and perlite-containing polyester filament yarns were the same. The fabrics were dyed with three medium level energy disperse dyes of different hues in order to observe the shade change caused by the intrinsic yellowness of the perlite-containing fabric. Dyeing and fastness properties of the dyed fabrics were evaluated by their corresponding lightness (L*), chroma (C*), color strength (K/S), and color difference (Delta E-ab*) results. The perlite-containing fabrics showed similar dyeing and fastness characteristics when compared with the regular fabrics. The perlite-added fabrics were dyed in darker color but had lower chroma values than the regular ones. The perlite-added fabrics also had better fastness results than the regular fabrics when the evaluation was performed in the group itself. Intrinsic yellowness of perlite-added fabrics must be taken into account for any attempt to dye the fabric to a pre-designed shade.Publication In vitro evaluation of electrospun polysaccharide based nanofibrous mats as surgical adhesion barriers(Ege Univ, 2020-01-01) Şafak, Şerife; Vatan, Özgür; VATAN, ÖZGÜR; Cinkılıç, Nilufer; ÇİNKILIÇ, NİLÜFER; Karaca, Esra; KARACA, ESRA; Fen Edebiyat Fakültesi; Tekstil Ana Bilim Dalı; 0000-0002-7687-3284; 0000-0002-3595-6286; 0000-0003-1777-3977; AAH-5296-2021; O-7508-2015; AAS-8480-2020; ISV-0209-2023Post-operative adhesions are one of the most important problems faced by patients and surgeons. In this study, nanofibrous mats were produced as novel surgical adhesion barrier from polysaccharide-based polymers, hyaluronic acid, carboxymethyl cellulose and sodium alginate, via electrospinning. The produced nanofibrous mats were crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide. Furthermore, the morphology, in vitro degradation, cytotoxicity and cell adherence potentials of the nanofibrous mats aimed to be used as adhesion barriers were evaluated and compared with a commercial adhesion barrier. Results of the in vitro experiment showed that the nanofibrous mats have maintained their physical structures during the critical period for adhesion formation, and had non-adherent cell feature and non-cytotoxic nature required for an ideal adhesion barrier.Publication Effects of fiber cross-sectional shapes on tensile and tearing properties of polyester woven fabrics(Ege Üniversitesi, 2015-10-01) Karaca, Esra; Ömeroğlu, Sunay; Becerir, Behçet; KARACA, ESRA; ÖMEROĞLU, SUNAY; BECERİR, BEHÇET; Mühendislik Fakültesi; Tekstil Mühendisliği Bölümü; 0000-0003-1777-3977; 0000-0002-2655-2773; AAH-1445-2021; AAM-7071-2020; AAS-8480-2020Breaking load and elongation, and tearing load properties of two type fabrics (plain and twill) woven from polyester fibers having round, hollow round, trilobal and hollow trilobal cross-sectional shapes were investigated. The fabrics produced from full fibers had higher breaking elongation and tearing load values but generally lower breaking load values than the fabrics produced from hollow fibers. The highest breaking load value was obtained in twill fabric woven from filaments having hollow round cross-sectional shape, while the highest tearing load value was obtained in twill fabric woven from filaments having round cross-sectional shape. The fabrics constituting filaments with round cross-sectional shapes had the highest breaking elongation values It was concluded that the effect of fiber cross-sectional shape on breaking strength and on tearing strength differed from each other.Publication The production and physical and thermal characterization of polybutylene succinate multifilament yarns(E.U. Printing and Publishing House, 2023-01-01) Kılınç, Kerim; Karaca, Esra; KARACA, ESRA; Mühendislik Fakültesi; Tekstil Mühendisliği Bölümü; AAS-8480-2020There are significant problems in the production, use and waste management of petroleum-based polymers due to the increasing plastic waste problem, exceeding limit of the greenhouse gas emissions and decreasing fossil resources. The textile sector is the second sector that causes the plastic waste problem after the packaging sector. About 65% of the total yarn produced in the textile industry consists of yarns obtained from petroleum-based polymers. Biopolymers come to the fore in studies carried out within the scope of sustainability philosophies such as using of renewable raw materials, recycling at the end of their life and decomposition without harming the nature. In this study, it is aimed to produce biobased and biodegradable polybutylene succinate (PBS) based polymer into multifilament yarn by melt spinning method and examine the effect of different winding speeds on the textile values of PBS yarns. In this context, multifilament yarns with round cross-sections were produced at four different winding speeds. The linear densities (dtex), elongations at maximum load and tenacities of the produced yarns were determined. The thermal characterization of PBS yarns were carried out by differential scanning calorimetry (DSC). The cross-sectional images of PBS filaments were taken and their diameters were measured, on an optical microscope. The results showed that as the winding speed increased, the elongation and dtex values decreased, while the tenacity and crystalinity values increased. It was determined that PBS filaments have smooth round cross-sections.Publication Preparation and characterization of latanoprost-loaded pva nanofibers as an ocular drug delivery system for glaucoma treatment(Taylor & Francis As, 2023-05-15) Karaca, Esra; KARACA, ESRA; Cesur, Merve İlkay Altuntuğ; Osman, Bilgen; OSMAN, BİLGEN; KANMAZ, DİLAYDA; TÜMAY ÖZER, ELİF; Baykara, Mehmet; BAYKARA, MEHMET; Tıp Fakültesi; Oftalmoloji Ana Bilim Dalı; 0000-0001-8406-149X; 0000-0002-5555-1649; 0000-0003-1777-3977; HSI-3968-2023; AAS-8480-2020In this study, latanoprost-loaded polyvinyl alcohol (PVA/LAT) nanofibers were developed as an ocular drug delivery system for glaucoma treatment. The nanofibers were constructed via electrospinning and crosslinked by glutaraldehyde. The characterization studies were conducted by scanning electron microscopy, Fourier Transform infrared spectroscopy, Brunauer, Emmett, and Teller analyses, water contact angle measurements, and also swelling and degradation studies. The PVA/LAT nanofibers crosslinked with 0.5% glutaraldehyde solution for 20 min had a cumulative release of 52% for 23 days. The results demonstrated that the PVA/LAT nanofibers have a usage potential as an ocular drug delivery system for glaucoma treatment.