Publication: Preparation and characterization of latanoprost-loaded pva nanofibers as an ocular drug delivery system for glaucoma treatment
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Date
2023-05-15
Authors
Karaca, Esra
Cesur, Merve İlkay Altuntuğ
Osman, Bilgen
Baykara, Mehmet
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis As
Abstract
In this study, latanoprost-loaded polyvinyl alcohol (PVA/LAT) nanofibers were developed as an ocular drug delivery system for glaucoma treatment. The nanofibers were constructed via electrospinning and crosslinked by glutaraldehyde. The characterization studies were conducted by scanning electron microscopy, Fourier Transform infrared spectroscopy, Brunauer, Emmett, and Teller analyses, water contact angle measurements, and also swelling and degradation studies. The PVA/LAT nanofibers crosslinked with 0.5% glutaraldehyde solution for 20 min had a cumulative release of 52% for 23 days. The results demonstrated that the PVA/LAT nanofibers have a usage potential as an ocular drug delivery system for glaucoma treatment.
Description
Keywords
Cross-linking, Release, Hydrogel, Membranes, Glutaraldehyde, Drug release, Electrospinning, Glaucoma, Latanoprost, Nanofiber, Polyvinyl alcohol, Science & technology, Technology, Physical sciences, Materials science, biomaterials, Polymer science, Materials science