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Preparation and characterization of latanoprost-loaded pva nanofibers as an ocular drug delivery system for glaucoma treatment

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dc.contributor.buuauthorKaraca, Esra
dc.contributor.buuauthorKARACA, ESRA
dc.contributor.buuauthorCesur, Merve İlkay Altuntuğ
dc.contributor.buuauthorOsman, Bilgen
dc.contributor.buuauthorOSMAN, BİLGEN
dc.contributor.buuauthorKANMAZ, DİLAYDA
dc.contributor.buuauthorTÜMAY ÖZER, ELİF
dc.contributor.buuauthorBaykara, Mehmet
dc.contributor.buuauthorBAYKARA, MEHMET
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentOftalmoloji Ana Bilim Dalı
dc.contributor.orcid0000-0001-8406-149X
dc.contributor.orcid0000-0002-5555-1649
dc.contributor.orcid0000-0003-1777-3977
dc.contributor.researcheridHSI-3968-2023
dc.contributor.researcheridAAS-8480-2020
dc.date.accessioned2024-11-26T05:23:30Z
dc.date.available2024-11-26T05:23:30Z
dc.date.issued2023-05-15
dc.description.abstractIn this study, latanoprost-loaded polyvinyl alcohol (PVA/LAT) nanofibers were developed as an ocular drug delivery system for glaucoma treatment. The nanofibers were constructed via electrospinning and crosslinked by glutaraldehyde. The characterization studies were conducted by scanning electron microscopy, Fourier Transform infrared spectroscopy, Brunauer, Emmett, and Teller analyses, water contact angle measurements, and also swelling and degradation studies. The PVA/LAT nanofibers crosslinked with 0.5% glutaraldehyde solution for 20 min had a cumulative release of 52% for 23 days. The results demonstrated that the PVA/LAT nanofibers have a usage potential as an ocular drug delivery system for glaucoma treatment.
dc.description.sponsorshipLatanoprost (414734) was donated by Abdi Ibrahim A.S. We offer our gratitude for their support.
dc.identifier.doi10.1080/00914037.2023.2213387
dc.identifier.endpage770
dc.identifier.issn0091-4037
dc.identifier.issue9
dc.identifier.startpage761
dc.identifier.urihttps://doi.org/10.1080/00914037.2023.2213387
dc.identifier.urihttps://hdl.handle.net/11452/48452
dc.identifier.volume73
dc.identifier.wos000987536400001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTaylor & Francis As
dc.relation.journalInternational Journal Of Polymeric Materials And Polymeric Biomaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCross-linking
dc.subjectRelease
dc.subjectHydrogel
dc.subjectMembranes
dc.subjectGlutaraldehyde
dc.subjectDrug release
dc.subjectElectrospinning
dc.subjectGlaucoma
dc.subjectLatanoprost
dc.subjectNanofiber
dc.subjectPolyvinyl alcohol
dc.subjectScience & technology
dc.subjectTechnology
dc.subjectPhysical sciences
dc.subjectMaterials science, biomaterials
dc.subjectPolymer science
dc.subjectMaterials science
dc.titlePreparation and characterization of latanoprost-loaded pva nanofibers as an ocular drug delivery system for glaucoma treatment
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentMühendislik Fakültesi/Tekstil Mühendisliği Ana Bilim Dalı
local.contributor.departmentFen Edebiyat Fakültesi/Kimya Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Oftalmoloji Ana Bilim Dalı
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