Publication: Carbapenem-resistant Gram-negative pathogens associated with septic shock: A review of 120 cases
No Thumbnail Available
Date
2022-04-16
Authors
Authors
Önal, Uğur
Akyol, Deniz
Mert, Merve
Baskol, Dilsah
Memetali, Seichan Chousein
Sanlidag, Gamze
Kenanoglu, Buse
Uyan-Onal, Ayse
Quliyeva, Gunel
Avsar, Cansu Bulut
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis Ltd
Abstract
This study aimed to evaluate the influencing variables for outcomes in patients with septic shock having culture-proven carbapenem-resistant Gram-negative pathogens. It included 120 patients (mean age 64.29 +/- 1.35 years and 58.3% female). The mean Sequential Organ Failure Assessment score during septic shock diagnosis was found to be 11.22 +/- 0.43 and 9 +/- 0.79 among the patients with mortality and among the survivors, respectively (P = 0.017). The logistic regression analysis showed that empirical treatment as mono Gram-negative bacteria-oriented antibiotic therapy (P = 0.016, odds ratio (OR) = 17.730, 95% confidence interval (CI): 1.728-182.691), Charlson Comorbidity Index >2 (P = 0.032, OR = 7.312, 95% CI: 5.7-18.3), and systemic inflammatory response syndrome score 3 or 4 during septic shock diagnosis (P = 0.014, OR = 5.675, 95% CI: 1.424-22.619) were found as independent risk factors for day 30 mortality. Despite early diagnosis and effective management of patients with septic shock, the mortality rates are quite high in CRGNP-infected patients.
Description
Keywords
Infectious-diseases-society, Clinical-practice guidelines, Management, Mortality, Sepsis, Pneumonia, Diagnosis, Adults, Carbapenem resistance, Gram-negative pathogens, Septic shock, Oncology, Infectious diseases, Pathology, Pharmacology & pharmacy