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Carbapenem-resistant Gram-negative pathogens associated with septic shock: A review of 120 cases

dc.contributor.authorÖnal, Uğur
dc.contributor.authorAkyol, Deniz
dc.contributor.authorMert, Merve
dc.contributor.authorBaskol, Dilsah
dc.contributor.authorMemetali, Seichan Chousein
dc.contributor.authorSanlidag, Gamze
dc.contributor.authorKenanoglu, Buse
dc.contributor.authorUyan-Onal, Ayse
dc.contributor.authorQuliyeva, Gunel
dc.contributor.authorAvsar, Cansu Bulut
dc.contributor.authorAkdag, Damla
dc.contributor.authorDemir, Melike
dc.contributor.authorErdem, Huseyin Aytac
dc.contributor.authorKahraman, Umit
dc.contributor.authorBozbiyik, Osman
dc.contributor.authorOzgiray, Erkin
dc.contributor.authorBozkurt, Devrim
dc.contributor.authorAkarca, Funda Karbek
dc.contributor.authorDemirag, Kubilay
dc.contributor.authorCankayali, Ilkin
dc.contributor.authorUyar, Mehmet
dc.contributor.authorCilli, Feriha
dc.contributor.authorArda, Bilgin
dc.contributor.authorYamazhan, Tansu
dc.contributor.authorPullukcu, Husnu
dc.contributor.authorTasbakan, Meltem Isikgoz
dc.contributor.authorSipahi, Hilal
dc.contributor.authorUlusoy, Sercan
dc.contributor.authorSipahi, Oguz Resat
dc.contributor.buuauthorÖNAL, UĞUR
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı,
dc.contributor.orcid0000-0001-6953-8499
dc.contributor.researcheridACQ-7832-2022
dc.date.accessioned2024-10-21T06:42:22Z
dc.date.available2024-10-21T06:42:22Z
dc.date.issued2022-04-16
dc.description.abstractThis study aimed to evaluate the influencing variables for outcomes in patients with septic shock having culture-proven carbapenem-resistant Gram-negative pathogens. It included 120 patients (mean age 64.29 +/- 1.35 years and 58.3% female). The mean Sequential Organ Failure Assessment score during septic shock diagnosis was found to be 11.22 +/- 0.43 and 9 +/- 0.79 among the patients with mortality and among the survivors, respectively (P = 0.017). The logistic regression analysis showed that empirical treatment as mono Gram-negative bacteria-oriented antibiotic therapy (P = 0.016, odds ratio (OR) = 17.730, 95% confidence interval (CI): 1.728-182.691), Charlson Comorbidity Index >2 (P = 0.032, OR = 7.312, 95% CI: 5.7-18.3), and systemic inflammatory response syndrome score 3 or 4 during septic shock diagnosis (P = 0.014, OR = 5.675, 95% CI: 1.424-22.619) were found as independent risk factors for day 30 mortality. Despite early diagnosis and effective management of patients with septic shock, the mortality rates are quite high in CRGNP-infected patients.
dc.identifier.doi10.1080/1120009X.2022.2064703
dc.identifier.endpage445
dc.identifier.issn1120-009X
dc.identifier.issue7
dc.identifier.startpage436
dc.identifier.urihttps://doi.org/10.1080/1120009X.2022.2064703
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/1120009X.2022.2064703
dc.identifier.urihttps://hdl.handle.net/11452/46760
dc.identifier.volume34
dc.identifier.wos000784492200001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.journalJournal of Chemotherapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInfectious-diseases-society
dc.subjectClinical-practice guidelines
dc.subjectManagement
dc.subjectMortality
dc.subjectSepsis
dc.subjectPneumonia
dc.subjectDiagnosis
dc.subjectAdults
dc.subjectCarbapenem resistance
dc.subjectGram-negative pathogens
dc.subjectSeptic shock
dc.subjectOncology
dc.subjectInfectious diseases
dc.subjectPathology
dc.subjectPharmacology & pharmacy
dc.titleCarbapenem-resistant Gram-negative pathogens associated with septic shock: A review of 120 cases
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication73351d49-e518-4e6a-8f69-c922f8f24611
relation.isAuthorOfPublication.latestForDiscovery73351d49-e518-4e6a-8f69-c922f8f24611

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