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The association between hematologic parameters and intracranial injuries in pediatric patients with traumatic brain injury running title: Haematologic parameters in paediatric head trauma

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Date

2022-05-26

Authors

Eser, Pınar
Corabay, Seniha
Özmarasali, Ali İmran
Ocakoğlu, Gökhan
Taşkapılıoğlu, Mevlut Özgür

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Taylor

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Abstract

Objective Analyzing the association between hematologic parameters and abnormal cranial computerized tomography (CT) findings after head trauma. Material and methods A total of 287 children with isolated traumatic brain injury (TBI) were divided into the 'normal' (NG), 'linear fracture' (LFG) and 'intraparenchymal injury' groups (IPG) based on head CT findings. Demographical/clinical data and laboratory results were obtained from medical records. Results The neutrophil-lymphocyte ratio was markedly higher in the LFG (p = 0.010 and p = 0.016, respectively) and IPG (p = 0.004 and p < 0.001, respectively) compared with NG. Lower lymphocyte-monocyte ratio (p = 0.044) and higher red cell distribution width-platelet ratio (RPR) (p = 0.030) were associated with intraparenchymal injuries. Patients requiring neurosurgical intervention had higher neutrophil-lymphocyte ratio (p = 0.026) and RPR values (p = 0.031) and lower platelet counts (p = 0.035). Lower levels of erythrocytes (p = 0.005), hemoglobin (p = 0.003) and hematocrit (p = 0.002) were associated with severe TBI and unfavorable outcome (p = 0.012, p = 0.004 and p = 0.006, respectively). Conclusions Hematologic parameters are useful in predicting the presence of abnormal cranial CT findings in children with TBI in association with injury severity; surgery need and clinical outcome.

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Keywords

Glasgow coma scale, Cell distribution width, To-lymphocyte ratio, Computed-tomography, Radiation-exposure, Motor score, Neutrophil, Mild, Anemia, Management, Glasgow coma score, Hematologic markers, Neurosurgery, Outcome, Pediatric patients, Traumatic brain injury, Science & technology, Life sciences & biomedicine, Neurosciences, Rehabilitation, Neurosciences & neurology

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