Publication: Corpus callosum in schizophrenia with deficit and non-deficit syndrome: A statistical shape analysis
Date
2021-10-27
Authors
Authors
Türk, Yaşar
Ercan, İlker
Şahin, İbrahim
Gürsel, Başak Erdemli
Uzunoğlu, Arda
Oğe, Cem
Beyazyüz, Elmas
Albayrak, Yakup
Journal Title
Journal ISSN
Volume Title
Publisher
Bmj Publishing Group
Abstract
Background The corpus callosum (CC) is the most targeted region in the cerebrum that integrates cognitive data between homologous areas in the right and left hemispheres.Aims Our study used statistical analysis to determine whether there was a correlation between shape changes in the CC in patients with schizophrenia (SZ) (deficit syndrome (DS) and non-deficit syndrome (NDS)) and healthy control (HC) subjects.Methods This study consisted of 27 HC subjects and 50 schizophrenic patients (20 with DS and 30 with NDS). 3 patients with DS and 4 patients with NDS were excluded. Three-dimensional, sagittal, T1-spoiled, gradient-echo imaging was used. Standard anatomical landmarks were selected and marked on each image using specific software.Results As to comparing the Procrustes mean shapes of the CC, statistically significant differences were observed between HC and SZ (DS+NDS) (p=0.017, James's F-j=73.732), HC and DS (p<0.001, James's F-j=140.843), HC and NDS (p=0.006, James's F-j=89.178) and also DS and NDS (p<0.001, James's F-j=152.967). Shape variability in the form of CC was 0.131, 0.085, 0.082 and 0.086 in the HC, SZ (DS+NDS), DS and NDS groups, respectively.Conclusions This study reveals callosal shape variations in patients with SZ and their DS and NDS subgroups that take into account the CC's topographic distribution.
Description
Keywords
White-matter, Magnetic-resonance, Structural abnormalities, Temporal-lobe, Brain, Individuals, 1ST-episode, Symptoms, Memory, Schizophrenia, Psychiatry, Neuropsychiatry, Biostatistics, Psychiatry