Publication:
An enflammatory marker in chronic renal failure patients: Visfatin

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2015-09-01

Authors

Ayar, Yavuz
Sayılar, Emel Işıktaş
Arslan, İsmail
Aksu, Çiğdem
Pektas, Fatih
Tüysüz, Özlem
Dirican, Melahat

Authors

Ayar, Yavuz
Sayılar, Emel Işıktaş
Yavuz, Mahmut
Arslan, İsmail
Aksu, Çiğdem
Ateş, Coşkun
Pektaş, Fatih
Tüysüz, Özlem
Topal, Naile Bolca
Dirican, Melahat

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Galenos Yayıncılık

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Abstract

Aim: Visfatin is a cytokine released from adipose tissue, especially in enflammation. In our study, we tried to show the relationship of visfatin levels with chronic renal failure (CRF) as an enflammatory marker.Methods: We included 50 CRF patients (28 male, 22 female) who attended Uludag University Nephrology Clinic and 31 healthy volunteers (13 male, 18 female). Visfatin levels and biochemical parameters, such as parathyroid hormone (PTH), lipid parameters, albumin, C-reactive protein (CRP), creatinine, urea, immunoglobulins, etc. were examined.Results: In CRF patients, visfatin levels were found to be significantly increased (p<0.001) and albumin, hemoglobin, body mass index (BMI) and high density lipoprotein (HDL) cholesterol levels were decreased (p<0.001). Triglycerides (p=0.003), CPR (p=0.005), procalcitonin (p<0.001), IgG3 (p=0.003), and ferritin (p<0.001) levels were significantly higher in patient group than in control group as an enflammatory marker.Conclusion: CRF is an independent enflammatory process. Visfatin levels in patients with chronic renal failure patients are determined to be high as an indicator of enflammation.

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Keywords

Adipose-tissue, Endothelial dysfunction, Plasma visfatin, Inflammation, Association, Atherosclerosis, Adipocytokines, Procalcitonin, Expression, Disease, Chronic renal failure, Visfatin, Enflammation, General & internal medicine

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