Publication: Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease
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Cansev, Mehmet
Ulus, İsmail Hakkı
Authors
Wang, Lei
Maher, Timothy John
Wurtman, Richard
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Elsevier
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Abstract
Administering uridine-5'-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins) and dendritic spines in rodents. We examined their effects on rotational behavior and dopaminergic markers in rats with partial unilateral 6-hydroxydopamine (6-OHDA)-induced striatal lesions. Rats receiving UMP, DHA, both, or neither, daily, and intrastriatal 6-OHDA 3 clays after treatment onset, were tested for d-amphetamine-induced rotational behavior and dopaminergic markers after 24 and 28 days, respectively. UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Hence, giving uridine and DHA may Partially restore dopaminergic neurotransmission in this model of Parkinson's disease.
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Keywords
Parkinson's disease, Uridine, Docosahexaenoic acid, Dopamine, Tyrosine hydroxylase activity, Synapse, Neurite outgrowth, Partial lesions, Fatty-acids, Brain, Dopamine, Supplementation, Release, Gerbils, Omega-3, System, Neurosciences & neurology
Citation
Cansev, M. vd. (208). ''Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease''. Neuroscience Research, 62(3), 206-209.