Yeni Yayınlar

Permanent URI for this collectionhttps://hdl.handle.net/11452/34996

Browse

Now showing 1 - 8 of 8

A neurosurgical assessment of the blood supply in the optochiasmatic system: A cadaveric-anatomic study
(Springer, 2021-01-05) Baykal, Duygu; Yılmazlar, Selçuk; Fedakar, Recep; Baykal, Duygu; YILMAZLAR, SELÇUK; FEDAKAR, RECEP; Tıp Fakültesi; Beyin Cerrahisi Ana Bilim Dalı; 0000-0003-3633-7919; AAH-5070-2021; AAH-6287-2021; GMD-4113-2022
The chiasmal and subchiasmal surfaces are of critical importance in connection with the performance of surgical procedures owing to the critical blood supply to these areas. Recently, the perforating arteries providing the blood to the optic nerves and chiasm have gained attention as they significantly affect the morbidity from surgical approaches. Intraoperative preservation of these perforating arteries is considered critical to prevent further visual loss. Thirty autopsy specimens, including the optic apparatus, were examined for their perforating arteries feeding the optic chiasm and optic nerves. The optic nerves and chiasmal surfaces were divided into four zones based on the presence and numbers of perforating arteries as anterior superior-posterior superior surfaces and anterior inferior-posterior inferior surfaces. The superior surface of the optic chiasm was supplied by the A1 segments of the bilateral anterior cerebral arteries and by the perforating arteries originating from the anterior communicating artery. On the other hand, the inferior surface of the optic chiasm was fed by the bilateral posterior communicating arteries and by the supraclinoidal segments of the bilateral carotid arteries. We demonstrated the anatomical involvement of a large number of nourishing arteries in feeding the optic apparatus related to the perforating arteries by classifying them into zones based on the surgical approaches, which has been rarely reported in the literature.
Ectopic prostate presenting as a mass in bladder
(Medknow Publications & Media Pvt Ltd, 2008-10-01) Eren, Filiz; Guzelsoy, Muhammet; Aydın, Övgü; Eren, Bülent; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0002-7249-4332; AAK-8096-2021; ABE-1189-2020; AFQ-4175-2022
A 24-year-old man presented with dysuria and voiding frequency. Cystoscopy revealed a smooth surfaced nodular mass in the trigonal region. Transurethral insisional biopsy of the mass was done. Histopathological and immunohistochemical examination revealed benign prostatic tissue situated ectopically.
Glial fibrillary acidic protein (GFAP) and CD34 expression in the human optic nerve and brain in methanol toxicity
(Springer, 2008-02-01) Türkmen, Nursel; Eren, Bülent; Fedakar, Recep; Akgöz, Semra; Comunoglu, Nil; TÜRKMEN İNANIR, NURSEL; Eren, Bülent; FEDAKAR, RECEP; Akgöz, Semra; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0002-2319-1757; JGZ-0807-2023; AAH-6287-2021; ACP-5545-2022; AAK-8096-2021
Introduction: The toxicity of methanol is as a result of its metabolites, formaldehyde and formic acid. Formic acid induces severe metabolic acidosis causing death, and is the primary agent responsible for ocular toxicity. Glial fibrillary acidic protein ( GFAP) immunostaining is the most commonly used method for examining astrocyte proliferation and hypertrophy after various central nervous system injuries. The antigen CD34 is expressed widely on vascular endothelium, including that of the central nervous system and high endothelial venules.Methods: In this study, GFAP and CD34 were immunohistochemically localised in the post-mortem optic nerve head, and brain tissue ( basal ganglia putamen) samples were collected from methanol-exposed and non-methanol-exposed ( control) subjects.Results: There was a positive correlation between the GFAP and CD34 intensity of staining scores in the methanol-exposed group ( P=0.711, P=0.010). Furthermore, there was also a positive correlation between the brain putamen and optic nerve head GFAP extent of staining in the methanol-exposed group ( P=0.720, P=0.008). A statistically significant difference was found between the methanol-exposed group and the control group optic nerve CD34 intensity scores ( P=0.014), but no significant difference was found between optic nerve CD34 and GFAP extent scores ( P=0.05).Conclusion: The study revealed that methanol affects brain putamen and the optic nerve selectively. We detected a positive significant correlation between brain and optic nerve GFAP expression. CD34 expression was markedly decreased by the toxic effects of methanol.
Immunohistochemical determination of hif, tsp-1, adamts1, and adamts8 expressions in the brains of alzheimer's disease patients: A preliminary autopsy study
(Erciyes Univ Sch Medicine, 2016-03-01) Eren, Filiz; Eren, Bülent; Demircan, Kadir; Akyol, Sümeyya; Aynekin, Büşra; TÜRKMEN İNANIR, NURSEL; Fedakar, Recep; FEDAKAR, RECEP; Gürses, Murat Serdar; Ural, Mustafa; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; JAC-4250-2023; ACP-5545-2022; AAH-6287-2021
Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease that mostly affects the elderly population. Recent studies performed in AD highlight the pathophysiological relevance of disintegrin and metalloproteinase with thrombospondin type 1-like motifs (ADAMTS) genes and their products, namely hypoxia inducible factor-1 (HIF-1) and thrombospondin-1 (TSP-1). Thus, the aim of this study was to describe and identify the distribution, characteristics, and any changes in the expression and immunoreactivity for HIF-1, TSP-1, and ADAMTS1 and 8 in AD brains.Materials and Methods: Nine patients who were autopsied in the Council of Forensic Medicine, Bursa Morgue Department in 2013, were selected. All patients were sent for autopsy to the Morgue Department within 8 h after death. At the autopsy, tissue samples of the organs were obtained for histopathological examination for determining the cause of death. Among these, two patients were clinically diagnosed with AD.Results: Immunohistochemical staining was performed, and the staining intensity/extensity was evaluated using a semi-quantitative scoring system. Median distribution (extensity) scores of the immunohistochemical staining were estimated as 2 for HIF-1, 0.67 for TSP-1, 3.11 for ADAMTS1, and 2.78 for ADAMTS8. Intensity scores were estimated as 1.22 for HIF-1, 0.56 for TSP-1, 3 for ADAMTS1, and 2.11 for ADAMTS8.Conclusion: Our study suggests that ADAMTS1 and ADAMTS8 expressions are not specific for AD. To understand and provide definitive data on all aspects of metalloproteinases, extracellular matrix proteins, and transcriptional factor effects to AD, further studies are needed, where other metalloproteinases and related molecules/enzymes should be studied.
Road traffic collisions in Bursa, Turkey, during 2003, 2004 and 2005
(Elsevier Sci Ltd, 2008-05-01) Durak, Dilek; Fedakar, Recep; Türkmen, Nursel; Akgöz, Semra; Baduroğlu, Erol; DURAK, DİLEK; FEDAKAR, RECEP; TÜRKMEN İNANIR, NURSEL; Akgöz, Semra; Baduroğlu, Erol; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0003-3469-340X; AAH-6587-2021; AAH-6287-2021; ACP-5545-2022; JGZ-0807-2023; ENO-6380-2022
Aim: To highlight the demographic pattern of road traffic injuries in Bursa and to improve emergency care and health facility-based treatment.Methods: Records of all registered road traffic collisions maintained by the Uludag University Emergency Department in Bursa for the period 2003 to 2005 and trauma files of 1307 road traffic collision victims were examined in this study. A form was designed to document patients' age, gender, type of trauma, time of trauma (hour, day, month and year), type and time to hospital of transport, presence of safety devices, presence of alcohol and blood alcohol concentration, localisations of wounds, trauma scores and outcomes.Results: Of the 1307 cases, 418 (32%) were female and 889 (68%) were mate. Ages ranged from 3 months to 87 years; mean age (+/-S.D.) was 34.8 (+/-17.3) years. The mean (+/-S.D.) ages of women and men were 35 +/- 17.6 and 34.7 +/- 17.2 years, respectively. Trauma was most commonly sustained within the motor vehicle (72.2%), followed by pedestrian injuries (21.7%), motorcycle injuries (5.5%) and bicycle injuries (0.6%). Collisions were most frequent in summer (34.7%) and on Fridays and weekends (48.5%). Seat belts were used in only 1.8% of incidents. In 90 cases (6.9%) alcohol was found in the blood; mean blood alcohol concentration was 139.2 +/- 88.3 mg/dl.Conclusions: The identification of RTC characteristics may contribute to the development of injury prevention measures. Road travel requires extra attentiveness at peak accident times. Seat-belt use should increase, as well as use of other safety equipment such as collision helmets. Shorter transportation time of casualties to hospital would improve outcome. (C) 2007 Elsevier Ltd. All rights reserved.
The anatomic variations and surgical windows among optic chiasm/nerves and carotid arteries in the sellar region play a role in choosing the best surgical approaches: A Cadaveric study
(Elsevier Espana, 2020-05-01) Baykal, Duygu; Yılmazlar, Selçuk; Fedakar, Recep; Baykal, Duygu; YILMAZLAR, SELÇUK; FEDAKAR, RECEP; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0001-9833-9392; 0000-0003-3633-7919; AAH-5070-2021; AAH-6287-2021; GMD-4113-2022
Objective: Understanding the relationship between the carotid artery, optic nerve and the anterior clinoid process is the basis of surgical approaches performed in the subchiasmal region. The location of the optic chiasm, the length of the optic nerves, and the distance and angle between the optic nerves determine the route of surgical approaches. We have determined the types of optic chiasm to study the relationship between vascular and neural structures in this region.Materials and methods: Thirty autopsy specimens were investigated at the Bursa Forensic Medicine Institute for optic chiasm types and the relationship between the neural and vascular anatomical structures of the sellar-parasellar and subchiasmal region was examined between June 2016 and November 2016.Results: In this study, 4 prefix types (13%), 6 postfix types (20%), and 20 central types (67%) of chiasm were defined. Furthermore, we measured this angle between two optic nerves, which indirectly shows the location of chiasm according to the diaphragma sellae, and then detected the mean value of this angle as 87.1 +/- 11.6 degrees. The "limit" value to designate a chiasm as prefix was measured in the current study as >= 101.1 degrees. T.he angle between optic nerves ranged from a mean value of 69.9 +/- 3.7 degrees in 6 cases with postfix chiasm, to a mean value of 104.0 +/- 2.1 degrees in 4 cases with prefix chiasm and a mean value of 88.8 +/- 6.7 degrees in 20 cases with central chiasm.Conclusion: In this study, we showed that the relationship among optic chiasma types, optic nerves and bony and vascular structures around the sellar area was effective at determining the surgical approach to this region. (C) 2019 Sociedad Espanola de Neurocirugia. Published by Elsevier Espana, S.L.U. All rights reserved.
The importance of hemosiderin deposition in the infant brain: An autopsy study
(Lithographia, 2015-01-01) İnanır, Türkmen N.; Eren, F.; Akgöz, S.; Eren, B.; Çetin, S.; Gündoğmuş, U. N.; Çomunoğlu, N.; Çomunoğlu, C.; TÜRKMEN İNANIR, NURSEL; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; ACP-5545-2022
Background/aim: Iron is an essential element involved in many metabolic processes. Presence and accumulation of iron in various body systems can result in different outcomes. Its accumulation in the central nervous system (CNS) cannot be detected routinely by application of hematoxylin-eosin staining. Detection of the presence of hemosiderin in the brain and cerebellum by application of Perls' dye is of importance in cases of infant deaths.Material and Methods: In this study, brain and cerebellar specimens obtained from 52 eligible infants (aged 0-1 years) autopsied in our institute between the years 2010 and 2013, independent of the cause of death, were analyzed in order to detect possible presence of hemosiderin. Perls' dye was used to detect histopathological staining intensity and distribution of hemosiderin in the brain and cerebellum.Results: Cases did not differ significantly as for the patients' age and gender (p = 0.473), type of the culprit trauma (p = 0.414), death/crime scene (p = 0.587), and diagnosis groups (p = 0.550). In this autopsy study blue colored hemosiderin granulations, stained with Perls' dye were detected in the brain (n: 39, 75%), and cerebellum (n: 35, 67.3%). A weakly negative, but significant correlation was detected between the postmortem interval and intensity values of cerebellar hemosiderin (Spearman's correlation coefficient: -0.381, p = 0.024). A statistically significant difference was found between the distribution scores of cerebral hemosiderin in cases with and without trauma history (p = 0.03). Median cerebral hemosiderin distribution scores were 2.5 and 2, respectively.Conclusions: The detection of a correlation between the presence of cerebral and cerebellar hemosiderin, and post-mortem interval in the age group of 0-1 years, should be interpreted as an important finding in the analysis of cerebral iron. The presence of hemosiderin in the CNS may be a significant finding in the elucidation of infant deaths and this procedure should be carried out on a routine basis.
Usability of dental pulp visibility and tooth coronal index in digital panoramic radiography in age estimation in the forensic medicine (vol 134, pg 381, 2020)
(Springer, 2020-05-01) Gök, Ertuğrul; Fedakar, Recep; Mustafa Kafa, İlker; FEDAKAR, RECEP; KAFA, İLKER MUSTAFA; Tıp Fakültesi; Adli Tıp Ana Bilim Dalı; 0000-0001-8309-0934; AAH-6287-2021; AAG-7125-2021

Browse

Browsing by Department "Adli Tıp Ana Bilim Dalı"