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Permanent URI for this collectionhttps://hdl.handle.net/11452/34996

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Browsing by Department "Alerji Bilim Dalı"

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    Frequency of atopy and allergic disorders among adults with type 1 diabetes mellitus in the southern marmara region of turkey
    (Springer, 2008-03-01) Duran, C.; Ediger, D.; Ersoy, C.; Coşkun, N. F.; Selimoğlu, H.; Ercan, I.; Kıyıcı, S.; Güçlü, M.; Sağlam, D. A.; Ertürk, E.; Tuncel, E.; İmamoğlu, S.; EDİGER, DANE; ERSOY, CANAN; Coşkun, N. Funda; Selimoğlu, Hadi; ERCAN, İLKER; Kıyıcı, Sinem; Güçlü, Metin; SAĞLAM, DİLEK; ERTÜRK, ERDİNÇ; Tuncel, Ercan; İMAMOĞLU, SÜLEYMAN; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; Göğüs Hastalıkları Bilim Dalı; 0000-0001-9560-180X; 0000-0002-2954-4293; 0000-0003-3604-8826; 0000-0002-2382-290X; 0000-0001-5082-9894; 0000-0003-3604-8826; AAJ-6536-2021; ABF-2367-2020; AAH-8861-2021; ABI-4847-2020; AAE-9142-2019; AAD-1271-2019; FWY-5938-2022; FGL-7924-2022; DNS-0810-2022; EBN-7188-2022; DEA-5443-2022
    Aim: Autoimmune disorders are considered to be associated with a Th1 immune response whereas allergic diseases with a Th2 response. Studies mainly per-Formed on children revealed conflicting results regarding the association of atopy/allergic disease and autoimmune disorders. Therefore, we aimed to investigate the prevalence of allergic diseases in adult Type 1 diabetic patients. Methods: Eighty-nine Type 1 diabetic patients and 64 controls were enrolled into the study. Skin-prick test and European Community Respiratory Health Survey questionnaire were performed on all cases. Patients who gave at least one positive answer to questions about asthma in the questionnaire underwent pulmonary function test and methacholine challenge test. Results: Patients' mean age were similar in diabetic patients and controls (28.2 +/- 8.9 and 28.1 +/- 5.2 yr; respectively). In skin-prick test, the rate Of Positive response to at least one allergen was not significantly different in diabetes (29.2%) and in the control group (31.3%). In European Community Respiratory Health Survey questionnaire, diabetic patients waked up by an attack of cough more than controls did. The rate of physician-diagnosed asthma was similar in both groups. There was no difference between the 2 groups based on the answers of other questions about asthma and other allergic diseases such as allergic rhinitis, eczema, and drug allergy. Conclusion: We found that atopy frequencies were similar in an adult population of Type 1 diabetic patients and controls. Although asthmatic symptom prevalence is increased in diabetic patients, the incidence of current asthma was similar in both groups.
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    Publication
    Is the subcutaneous allergen immunotherapy safe enough as a treatment modality?
    (Bilimsel Tıp Yayınevi, 2010-01-01) Ediger, Dane; Yılmaz, Dilber; Coşkun, Funda; Gözü, Oktay; EDİGER, DANE; Yılmaz, Dilber; COŞKUN, NECMİYE FUNDA; Gözü, Oktay; Tıp Fakültesi; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; Göğüs Hastalıkları Ana Bilim Dalı; Alerji Bilim Dalı; 0000-0002-2954-4293; 0000-0003-3604-8826; AAD-1271-2019; AAE-9142-2019; EGU-1690-2022; EWV-3115-2022
    Objective: Allergen immunotherapy has been proven to be effective and potentially curative therapy in allergic respiratory diseases and in venom allergy. But occurance of adverse systemic reactions due to specific allergen immunotherapy (SIT) remains still major problem. In this study we aimed to assess the adverse reactions of SIT which has been given to patients diagnosed as allergic asthma and/or rhinitis.Materials and Methods: The 58 patients (37 female/21 male) followed up at Allergy Outpatient and received SIT were included to the study. Local or systemic reactions that occured during total 2939 injections were analyzed.Results: Total 2939 injections with standardized allergen extracts were administered to patients diagnosed as allergic asthma (n= 9), allergic rhinitis (n= 6), allergic asthma and allergic rhinitis (n= 43). Total 39 (1.3%) reactions were observed in 15 (25.8%) patients. Among these reactions 20 ones were local and 19 ones were systemic reactions. Among reactions 15 (75%) of local and 14 (73.7%) of systemic were occurred during build-up phase; 5 (25%) of local and 5 (26.3%) of systemic were occurred during maintenance phase (p< 0.05). According to allergen type while among systemic reactions 13 (68.4%) occured by polen extracts and 6 (31.6%) by mite extracts, among local reactions 15 (75%) occurred by polen extracts and 5 (25%) by mite extracts. (p< 0.05). These systemic reactions were urticaria, itching of body, flushing and feeling of fever, dyspnea and vertigo/headache. Reactions due to grass polen allergen occurred during season were two systemic and one local reaction.Conclusion: We believe that spesific immunotherapy is safe when used with strict safety protocols and administered by staff specialized in allergy. It is needed to have more researches to determine the factors predisposing the adverse reactions to SIT.