Publication: Morphometric shape analysis of corpus callosum in children with down syndrome
Date
2023-08-31
Authors
Authors
Gürsel, Başak Erdemli
Ercan, İlker
Şahin, İbrahim
Öngen, Gökhan
Journal Title
Journal ISSN
Volume Title
Publisher
Sage Publications Inc
Abstract
Down syndrome (DS) is characterized by varying degrees of mental retardation and delay in neurocognitive functions. Herein, we analyzed the morphometric shape of the corpus callosum (CC) in children with DS. Twenty-three DS cases underwent magnetic resonance imaging and have grossly normal CC, and 23 control group cases were included in this retrospective study (2012-2020). The CC was obtained from T2-weighted mid-sagittal images, and certain anatomical points were marked on the CC. Statistical geometric shapes and deformations of CC were evaluated for both groups. The age range of patients with DS and control group was 6 to 42 months. A statistically significant difference was found in the shape of CC between the groups (P < .001). Deformation was most evident in the splenium in the DS group.
Description
Keywords
Brain, Morphology, Down syndrome, Corpus callosum, Splenium, Shape analysis, Pediatrics